The institution of reference nutrient intake on phosphate, aimed reduction for cardiovascular disease risk

• Project/Area Number: 20800038
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: The University of Tokushima
• Principal Investigator: SHUTO Emi The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (10512121)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 動脈硬化 / リン / 酸化ストレス / 心血管疾患

Research Abstract

Excessive dietary phosphorus may increase cardiovascular risk in healthy individuals as well as in patients with chronic kidney disease. To determine whether postprandial hyperphosphatemia may promote endothelial dysfunction, we investigated the acute effect of phosphorus loading on endothelial function in 11 healthy men. The high dietary phosphorus load increased serum phosphorus and significantly decreased flow-mediated dilation. Flow-mediated dilation correlated inversely with serum phosphorus. These findings suggest that endothelial dysfunction mediated by acute postprandial hyperphosphatemia may contribute to the relationship between serum phosphorus level and the risk for cardiovascular morbidity and mortality.

Research Products

• [Journal Article] Dietary phosphorus acutely impairs endothelial function. (2009)
  • Author(s): Emi Shuto, Yutaka Taketani, Rieko Tanaka, agakatsu Harada, Masashi lsshiki, Minako Sato, Kunitaka Nashiki, Kikuko Amo, Hironori Yamamoto, Yukihito Higashi, Yutaka Nakaya, Eiji Takeda
  • Journal Title: Journal of the American Society of Nephrology Vol.20 Pages: 1504-1512
  • Peer Reviewed
• [Journal Article] Dietary Phosphorus Acutely Impairs Endothelial Function (2009)
  • Author(s): Shuto E, et al
  • Journal Title: Journal of the American Society of Nephrology 20 Pages: 1504-1512
  • Peer Reviewed
• [Journal Article] 高リン血症と心血管疾患 (2008)
  • Author(s): 首藤恵泉
  • Journal Title: 四国医学雑誌 64(3,4) Pages: 114-116
  • Peer Reviewed
• [Journal Article] Postprandial Hyperphosphatemia is a Novel Risk Factor for Cardiovascular Disease by Involving Endothelial Dysfunction (2008)
  • Author(s): Shuto E, et al
  • Journal Title: Journal of Bone Mineral Reseadch 23
  • Peer Reviewed
• [Journal Article] リンの栄養学 (2008)
  • Author(s): 竹谷 豊 等
  • Journal Title: The Bone 22(6) Pages: 737-741
  • Peer Reviewed
• [Journal Article] 高リン血症と心血管疾患 (2008)
  • Author(s): 首藤 恵泉 等
  • Journal Title: 四国医学雑誌 64(3, 4) Pages: 114-116
  • Peer Reviewed
• [Presentation] 食事性のリン過剰摂取は血管内皮機能を障害する (2010)
  • Author(s): 首藤恵泉
  • Organizer: 第13回日本病態栄養学会年次学術集会
  • Place of Presentation: 京都
• [Presentation] 食事性のリン過剰摂取は血管内皮機能を障害する (2010)
  • Author(s): 首藤恵泉, 等
  • Organizer: 第13回日本病態栄養学会年次学術集会
  • Place of Presentation: 京都市
• [Presentation] Excessive dietary phosphorus acutely impairs endothelial function in healthy men. (2009)
  • Author(s): Emi Shuto
  • Organizer: The American Society of Nephrology 42nd ANNUAL MEETING & Scientific Exposition
  • Place of Presentation: San Diego, California, America
• [Presentation] ヒトにおける食事性高リン負荷による血管内皮機能障害 (2009)
  • Author(s): 首藤恵泉
  • Organizer: 第63回日本栄養・食糧学会大会
  • Place of Presentation: 長崎
• [Presentation] ヒトにおける食事性高リン負荷による血管内皮機能障害 (2009)
  • Author(s): 首藤恵泉
  • Organizer: 第12回日本病態栄養学会年次学術集会
  • Place of Presentation: 京都
• [Presentation] Acute effect of elevation of serum phosphorus on endothelial function with reference to oxidative stress and NO production (2009)
  • Author(s): Taketani Y, et al
  • Organizer: 36th international congress of physiological science
  • Place of Presentation: 東京
• [Presentation] Dual Role of Type III Sodium-Dependent Phosphate Transporter in the Pathogenesis of Arteriosclerosis Caused by Hyperphosphatemia (2009)
  • Author(s): Taketani Y, et al
  • Organizer: American Society of Bone and Mineral Research 31th ANNUAL MEETING
  • Place of Presentation: Denver, Colorado, USA
• [Presentation] Excessive dietary phosphorus acutely impairs endothelial function in healthy men (2009)
  • Author(s): Shuto E, et al
  • Organizer: The American Society of Nephrology 42nd ANNUAL MEETING & Scientific Exposition
  • Place of Presentation: San Diego, California, America
• [Presentation] Fluctuation of Serum Phosphorus Levels Impairs Endothelial Function in Rats (2009)
  • Author(s): Watari E, et al
  • Organizer: The American Society of Nephrology 42nd ANNUAL MEETING & Scientific Exposition
  • Place of Presentation: San Diego, California, America
• [Presentation] ヒトにおける食事性高リン負荷による血管内皮機能障害 (2009)
  • Author(s): 首藤恵泉, 等
  • Organizer: 第63回日本栄養・食糧学会大会
  • Place of Presentation: 長崎市
• [Presentation] 高リン食は血管内皮依存性の血管弛緩反応を低下させる (2009)
  • Author(s): 渡里恵梨子, 等
  • Organizer: 第63回日本栄養・食糧学会大会
  • Place of Presentation: 長崎市
• [Presentation] 高リン負荷による血管内皮細胞におけるMCP-1の発現誘導 (2009)
  • Author(s): 北村知世, 等
  • Organizer: 第63回日本栄養・食糧学会大会
  • Place of Presentation: 長崎市
• [Presentation] 成人女性におけるリン制限食による尿中ミネラル排泄への影響 (2009)
  • Author(s): 西田由香, 等
  • Organizer: 第63回日本栄養・食糧学会大会
  • Place of Presentation: 長崎市
• [Presentation] 栄養素代謝恒常性の破綻と疾患発症におけるトランスポーターの役割 (2009)
  • Author(s): 竹谷豊, 等
  • Organizer: 第4回トランスポーター研究会
  • Place of Presentation: 京都市
• [Presentation] 高リン血症による血管内皮機能障害とその発生機序についての検討 (2008)
  • Author(s): 首藤 恵泉
  • Organizer: 第237回徳島医学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2008-08-03
• [Presentation] 高リン負荷による血管内皮機能障害 (2008)
  • Author(s): 首藤恵泉
  • Organizer: 第26回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] PostprandialIfyperphosphatemia is a Novel Risk Factor for Cardiovascular Disease by Involving Endothelial Dysfunction. (2008)
  • Author(s): Shuto E.
  • Organizer: American Society of Bone and Mineral Research 30th ANNUAL MEETING
  • Place of Presentation: Montreal, Quebec, Canada
• [Presentation] 食後高リン血症は血管内皮機能障害を惹起し心血管疾患のリスクとなる (2008)
  • Author(s): 首藤恵泉
  • Organizer: 第55回栄養改善学会
  • Place of Presentation: 鎌倉
• [Presentation] Postprandial Hyperphosphatemia is a Novel Risk Factor for Cardiovascular Disease by Involving Endothelial Dysfunction (2008)
  • Author(s): Shuto E
  • Organizer: American Society of Bone and Mineral Research 30th ANNUAL MEETING
  • Place of Presentation: Montreal, Quebec, Canada
• [Presentation] リン酸トランスポーターを介した血管内皮機能障害のメカニズム (2008)
  • Author(s): 首藤 恵泉
  • Organizer: トランスポーター研究会
  • Place of Presentation: 京都
• [Presentation] 高リン負荷による血管内皮機能障害 (2008)
  • Author(s): 首藤恵泉
  • Organizer: 第26回 日本骨代謝学会学術集会
  • Place of Presentation: 大阪