Delivery of siRNA to central nervous system viablood-brain barrirer transport : Therapy for prion disease
Project/Area Number |
20800066
|
Research Category |
Grant-in-Aid for Young Scientists (Start-up)
|
Allocation Type | Single-year Grants |
Research Field |
Biomedical engineering/Biological material science
|
Research Institution | Fukuoka University |
Principal Investigator |
WATANABE Takuya Fukuoka University, 薬学部, 助教 (90509647)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
|
Keywords | 薬学 / 感染症 |
Research Abstract |
This study aimed to develop new therapy for prion diease without side effects, using a complex of siRNA and RVG-9R. The siRNA decreased expression of prion mRNA and prion protein of scrapie form (PrP^<Sc>). And siRNA/RVG-9R complex bound to cell. However, treatment of siRNA/RVG-9R complex did not affect PrP^<Sc> level in prion-infected cell culture. Sequence of RVG-9R needs to optimize for knock-down of prion.
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Report
(3 results)
Research Products
(2 results)