Investigation of the molecular functions of Septin family molecules

• Project/Area Number: 20800086
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Institute for Developmental Research, Aichi Human Service Center
• Principal Investigator: SHINODA Tomoyasu Institute for Developmental Research, Aichi Human Service Center, 研究員 (80505652)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 大脳皮質 / 神経発生 / 細胞遊走 / 細胞生物学 / 大脳皮質発生

Research Abstract

Septin family molecules are highly conserved in eukaryotic cells. Although everal septins are specifically expressed in neuronal tissues, little is known about their physiological functions. Our research revealed that Sept14 is involved in cortical neuronal migration during corticogenesis, via interaction with Sept4.

Research Products

• [Journal Article] Septin 14 is involved in cortical neuronal migration via interaction with Septin 4. (2010)
  • Author(s): Shinoda T, Ito H, Sudo K, Iwamoto I, Morishita R, Nagata K.
  • Journal Title: Molecular Biology of the Cell 21 Pages: 1324-1334
  • Peer Reviewed
• [Journal Article] Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation. (2010)
  • Author(s): Ito H, Morishita R, Shinoda T, Iwamono I, Okamoto K, Nagata K.
  • Journal Title: Molecular Psychiatry 15 Pages: 976-986
  • Peer Reviewed
• [Journal Article] Proteomic analysis reveals novel binding partners of dysbindin, a schizophrenia-related protein. (2009)
  • Author(s): Hikita T, Taya S, Fujino Y, Taneichi-Kuroda S, Ohta K, Tsuboi D, Shinoda T, Kuroda K, Funahashi Y, Uraguchi-Asaki J, Hashimoto R, Kaibuchi K.
  • Journal Title: Journal of Neurochemistry 110 Pages: 1567-1574
  • Peer Reviewed
• [Presentation] 大脳皮質形成におけるSeptinファミリー分子の機能 (2010)
  • Author(s): 篠田友靖
  • Organizer: 愛知県心身障害者コロニー発達障害研究所公開シンポジウム
  • Place of Presentation: 愛知
  • Year and Date: 2010-12-22
• [Presentation] Molecular mechanism of septin-mediated neuronal migration (2010)
  • Author(s): 篠田友靖, ほか
  • Organizer: BMB2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] Sept14 is involved in neuronal migration via interaction with Sept4 (2010)
  • Author(s): 篠田友靖, et. al.
  • Organizer: Neuroscience2010
  • Place of Presentation: San Diego
  • Year and Date: 2010-11-13
• [Presentation] Septinの大脳皮質形成における機能および分子メカニズム (2010)
  • Author(s): 篠田友靖, ほか
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-08
• [Presentation] Septin 14 is involved in cortical neuronal migration via interaction with Septin 4 (2010)
  • Author(s): 篠田友靖, ほか
  • Organizer: 第74回生化学会中部支部例会・シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2010-06-23
• [Presentation] Roles of Septins in Neuronal Migration (2009)
  • Author(s): 篠田友靖, ほか
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] Novel function of Septin in neuronal migration (2009)
  • Author(s): 篠田友靖, ほか
  • Organizer: 名古屋大学グローバルCOEプログラム第2回国際シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-18
• [Presentation] Sept14の大脳皮質形成における機能 (2009)
  • Author(s): 篠田友靖, ほか
  • Organizer: Neuro2009
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-06
• [Presentation] Sept14 is involved in the proper positioning of cortical pyramidal neuron (2009)
  • Author(s): 篠田友靖
  • Organizer: 第1回名古屋大学大学院医学系研究科グローバルCOE国際シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-01-23
• [Presentation] Sept14 is involved in proper positioning of cortical pyramidal neuron (2009)
  • Author(s): 篠田友靖, ほか
  • Organizer: 名古屋大学グローバルCOEプログラム第1回国際シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-01-22
• [Presentation] Possible function of a multiadaptor protein, p140Cap, in exocytosis (2008)
  • Author(s): 篠田友靖, ほか
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] Possible functione of a multi domain adaptor protein, p140CAP, in exocytosis (2008)
  • Author(s): 篠田友靖
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会合同大会(BMB2008)
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] Sept14の皮質神経細胞局在下における機能 (2008)
  • Author(s): 篠田友靖
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
  • Year and Date: 2008-09-11
• [Presentation] Sept14の皮質神経細胞局在化における機能 (2008)
  • Author(s): 篠田友靖, ほか
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
  • Year and Date: 2008-09-08
• [Presentation] 統合失調症発症脆弱性因子DISC1の機能解析 (2008)
  • Author(s): 篠田友靖
  • Organizer: 第72回日本生化学会中部支部例会
  • Place of Presentation: 岐阜
  • Year and Date: 2008-05-24
• [Presentation] 統合失調症発症脆弱性因子DISC1の機能解析 (2008)
  • Author(s): 篠田友靖, ほか
  • Organizer: 第72回日本生化学会中部支部例会・シンポジウム
  • Place of Presentation: 岐阜
  • Year and Date: 2008-05-20
• [Book] SNARE複合体形成におけるセプチンの役割(61) (2010)
  • Author(s): 伊東秀記、篠田友靖、永田浩一
  • Publisher: 生体の科学
• [Book] 統合失調症脆弱性遺伝子DISC1の生理機能(34) (2008)
  • Author(s): 篠田友靖
  • Publisher: Medical Science Digest
• [Remarks] ホームページ等
  • URL: http://www.inst-hsc.jp