Generation of novel small-molecule drug targeting protein kinase epsilon for type 2 diabetes mellitus.

Research Project

Project/Area Number	20810031
Research Category	Grant-in-Aid for Young Scientists (Start-up)
Allocation Type	Single-year Grants
Research Field	Applied genomics
Research Institution	Tokai University
Principal Investigator	YONEZAWA Tomo Tokai University, 医学部, 奨励研究員 (60515964)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
Keywords	2型糖尿病 / プロテインキナーゼCε(PKCε) / 低分子化合物 / トランスレーショナルリサーチ / マイクロサテライト解析 / ゲノム / 糖尿病
Research Abstract	We identified the susceptible gene as a protein kinase C epsilon(PKCε) for type 2 diabetes mellitus via genome-wide association study using microsatellites, prompting us to generate the small molecule drug targeting PKCε. Our in silico strategy using 60,000 chemical library identified several potential modulators of PKCε activity. We also confirmed the effect of modulators on molecular-and cell-based assay.

Report

(3 results)