Development of PET-switch based fluorescent probe for RNA detection

• Project/Area Number: 20810037
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Living organism molecular science
• Research Institution: Kanagawa University
• Principal Investigator: OKAMOTO Itaru Kanagawa University, 工学部, 助手 (40460133)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,107,000 (Direct Cost: ¥2,390,000、Indirect Cost: ¥717,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,547,000 (Direct Cost: ¥1,190,000、Indirect Cost: ¥357,000)
• Keywords: RNA検出 / ボロン酸 / 光誘起電子移動 / 核酸 / 蛍光 / 分子認識

Research Abstract

In recent years, a large number of RNAs play an important role in the regulation of gene expression. Therefore, the research of RNAs become now imporatnt topics. In this study, we designed and evalueted novel probe for sequence selective RNA detection.

Research Products

• [Presentation] フェニルボロン酸を利用したRNA検出プローブ (2010)
  • Author(s): 岡本到
  • Organizer: 日本化学会春季年会
  • Place of Presentation: 大阪(近畿大学)
  • Year and Date: 2010-03-29
• [Presentation] フェニルボロン酸を利用したRNA検出プローブの開発 (2010)
  • Author(s): 岡本到・藤井紫乃・小野晶
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学本部キャンパス
  • Year and Date: 2010-03-26
• [Presentation] フェニルボロン酸構造をもつRNA検出センサーの開発 (2009)
  • Author(s): 岡本 到
  • Organizer: 日本化学会春季年会
  • Place of Presentation: 千葉
  • Year and Date: 2009-03-27
• [Presentation] フェニルボロン酸構造をもつRNA検出センサーの開発 (2009)
  • Author(s): 岡本到・藤井紫乃・小野晶
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 日本大学理工学部船橋キャンパス