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Design and fabrication of high-strength hydrogel formed from tetra-arm macromonomers

Research Project

Project/Area Number 20850012
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Polymer/Textile materials
Research InstitutionThe University of Tokyo

Principal Investigator

SAKAI Takamasa  The University of Tokyo, 大学院・工学系研究科, 特任助教 (70456151)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,289,000 (Direct Cost: ¥2,530,000、Indirect Cost: ¥759,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,729,000 (Direct Cost: ¥1,330,000、Indirect Cost: ¥399,000)
Keywordsハイドロゲル / スターポリマー / 医用構造材料 / 均一網目構造 / 理想高分子網目 / 再生医療
Research Abstract

We have developed the Tetra-PEG gel having extremely homogeneous network structure from tetra-arm polyethyleneglycol (Tetra-PEG). Tetra-PEG gel is easily formed by mixing two Tetra-PEG solutions, and have high mechanical strength originated from its homogeneities. Because Tetra-PEG gel has highly homogeneous network structure, toughness, biocompatibility, and high operatively, it is expected to be applied to the biomedical field, and contribute to the further development of polymer physics.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (42 results)

All 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (26 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Evaluation of topological defects in Tetra-PEG gels2010

    • Author(s)
      Y. Akagi, T. Matsunaga, M. Shibayama, U. Chung, T. Sakai
    • Journal Title

      Macromolecules 43

      Pages: 488-493

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of topological defects in Tetra-PEG gels2010

    • Author(s)
      赤木友紀
    • Journal Title

      Macromolecules 43

      Pages: 488-493

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of gelation kinetics of Tetra-PEG gel2010

    • Author(s)
      倉員麻奈実
    • Journal Title

      Macromolecules 43

      Pages: 3935-3940

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure Characterization of Tetra-PEG Gel by Small-Angle Neutron Scattering2009

    • Author(s)
      T. Matsunaga, T. Sakai (co-first), Y. Akagi, UI. Chung, M. Shibayama
    • Journal Title

      Macromolecules 42

      Pages: 4-1344

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] SANS and SLS Studies on Tetra-Arm PEG Gels in As-Prepared and Swollen States2009

    • Author(s)
      T. Matsunaga, T. Sakai (co-first), Y. Akagi, UI. Chung, M. Shibayama
    • Journal Title

      Macromolecules 42

      Pages: 6245-6245

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] SANS and SLS Studies on Tetra-Arm PEG Gels in As-Prepared and Swollen States2009

    • Author(s)
      松永拓郎
    • Journal Title

      Macromolecules 42

      Pages: 6245-6252

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure Characterization of Tetra-PEG Gel by Smal-Angle Neutron Scattering2009

    • Author(s)
      T, Matsunaga, T. Sakai, Y. Akagi, U, Chung, and M. Shibayama
    • Journal Title

      Macromolecules 42

      Pages: 1344-1351

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and fabrication of a high-strength hydrogel with ideally homogeneous network structure from tetrahedron-like macromonomers2008

    • Author(s)
      T. Sakai, T. Matsunaga, Y. Yamamoto, C. Ito, R. Yoshida, S. Suzuki, N. Sasaki, M. Shibayama, UI. Chung
    • Journal Title

      Macromolecules 41

      Pages: 14-5379

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Design and Fabrication of a High-Strength Hydrogel with Ideally Homogeneous Network Structure from Tetrahedron-like Macromonomers2008

    • Author(s)
      T. Sakai, T. Matsunaga, Y. Yamamoto, C. Itoh, R. Yoshida, S. Suzuki, N, Sasaki, M. Shibayama, and U. Chung
    • Journal Title

      Macromolecules 41

      Pages: 5379-5384

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of gelation kinetics of Tetra-PEG gel

    • Author(s)
      M. Kurakazu, T. Katashima (co-first), M. Chijiishi, K. Nishi, Y. Akagi, T. Matsunaga, M. Shibayama, U. Chung, T. Sakai
    • Journal Title

      Macromolecules (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] Tetra-PEGゲルにおけるトポロジカル不均一性の評価2010

    • Author(s)
      赤木友紀
    • Organizer
      第21回高分子ゲル研究討論会
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2010-01-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Tetra-PEGゲルのゲル化反応におけるpH,イオン強度の影響2010

    • Author(s)
      倉員麻奈実
    • Organizer
      第21回高分子ゲル研究討論会
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2010-01-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Tetra-PEGゲルのゲル化過程と力学的特性に与える温度と濃度の効果2010

    • Author(s)
      西健吾
    • Organizer
      第21回高分子ゲル研究討論会
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2010-01-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Tetra-PEGゲル内における物質拡散挙動解析2010

    • Author(s)
      筒井裕亮
    • Organizer
      第21回高分子ゲル研究討論会
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2010-01-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Tetra-PEG ゲルにおけるトポロジカル不均一性の評価2010

    • Author(s)
      赤木友紀, 倉員麻奈実, 松永拓郎, 柴山充弘, 鄭雄一, 酒井崇匡
    • Organizer
      第21回高分子ゲル研究討論会
    • Place of Presentation
      東京大学 山上会館
    • Related Report
      2009 Final Research Report
  • [Presentation] Tetra-PEG ゲルのゲル化反応におけるpH, イオン強度の影響2010

    • Author(s)
      倉員麻奈実, 鄭雄一, 酒井崇匡
    • Organizer
      第21回高分子ゲル研究討論会
    • Place of Presentation
      東京大学 山上会館
    • Related Report
      2009 Final Research Report
  • [Presentation] Tetra-PEG ゲルのゲル化過程と力学的特性に与える温度と濃度の効果2010

    • Author(s)
      西健吾, 千々石雅志, 鄭雄一, 酒井崇匡
    • Organizer
      第21回高分子ゲル研究討論会
    • Place of Presentation
      東京大学 山上会館
    • Related Report
      2009 Final Research Report
  • [Presentation] Tetra-PEG ゲル内における物質拡散挙動解析2010

    • Author(s)
      筒井裕亮, 李響, 鄭雄一, 酒井崇匡
    • Organizer
      第21回高分子ゲル研究討論会
    • Place of Presentation
      東京大学 山上会館
    • Related Report
      2009 Final Research Report
  • [Presentation] Tetra-PEG ゲルにおけるトポロジカル不均一性の評価2010

    • Author(s)
      赤木友紀, 松永拓郎, 柴山充弘, 鄭雄一, 酒井崇匡
    • Organizer
      第90回日本化学会春季年会
    • Place of Presentation
      近畿大学
    • Related Report
      2009 Final Research Report
  • [Presentation] 均一網目構造を有するTetra-Gelの構造と物性2009

    • Author(s)
      酒井崇匡
    • Organizer
      バイオマテリアル若手研究会
    • Place of Presentation
      八王子セミナーハウス(東京)
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] High-Strength Hydrogel with Highly Homogeneous Network Structure from Tetrahedron-like Macromers2009

    • Author(s)
      酒井崇匡
    • Organizer
      FAPS 2009
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Tetra-PEGゲルの網目構造と力学特性2009

    • Author(s)
      酒井崇匡
    • Organizer
      第57回高分子学会討論会
    • Place of Presentation
      熊本大学(熊本県)
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 四官能性マクロマーからなるTetra-PEG Gelの力学物性に及ぼす架橋点間分子量の効果2009

    • Author(s)
      赤木友紀
    • Organizer
      第57回高分子学会討論会
    • Place of Presentation
      熊本大学(熊本県)
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 異なる分子量を有する四分岐マクロマーからなるTetra-PEGゲルの構造と物性2009

    • Author(s)
      吉村智尋
    • Organizer
      第57回高分子学会討論会
    • Place of Presentation
      熊本大学(熊本県)
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 均一網目構造を有するTetra-PEGゲルからの薬物放出挙動の制御2009

    • Author(s)
      塚田篤
    • Organizer
      第57回高分子学会討論会
    • Place of Presentation
      熊本大学(熊本県)
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Tetra-PEG ゲルの網目構造と力学特性2009

    • Author(s)
      酒井崇匡, 赤木友紀, 倉員麻奈実, 吉村千尋, 塚田篤, 鄭雄一, 松永拓郎, 柴山充弘
    • Organizer
      第20回高分子ゲル研究討論会
    • Place of Presentation
      東京大学 山上会館
    • Related Report
      2009 Final Research Report
  • [Presentation] Tetra-PEG ゲルの網目構造と力学特性2009

    • Author(s)
      酒井崇匡, 赤木友紀, 倉員麻奈実, 吉村千尋, 塚田篤, 鄭雄一, 松永拓郎, 柴山充弘
    • Organizer
      第57回高分子学会討論会
    • Place of Presentation
      熊本大学
    • Related Report
      2009 Final Research Report
  • [Presentation] 四官能性マクロマーからなる Tetra-PEG Gel の力学物性に及ぼす架橋点間分子量の効果2009

    • Author(s)
      赤木友紀, 倉員麻奈実, 松永拓郎, 石井武彦, 柴山充弘, 鄭雄一, 酒井崇匡
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本大学
    • Related Report
      2009 Final Research Report
  • [Presentation] 異なる分子量を有する四分岐マクロマーからなる Tetra-PEG ゲルの構造と物性2009

    • Author(s)
      吉村智尋, 鄭雄一, 酒井崇匡
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本大学
    • Related Report
      2009 Final Research Report
  • [Presentation] 均一網目構造を有する Tetra-PEG ゲルからの薬物放出挙動の制御2009

    • Author(s)
      塚田篤, 筒井裕亮, 鄭雄一, 酒井崇匡
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本大学
    • Related Report
      2009 Final Research Report
  • [Presentation] 均一網目構造を有する Tetra-Gel の構造と物性2009

    • Author(s)
      酒井崇匡
    • Organizer
      バイオマテリアル若手研究会
    • Related Report
      2009 Final Research Report
  • [Presentation] Design and Fabrication of a High-Strength Hydrogel with ideally Homogeneous Network Structure from Tetrahedron-like Macromers2009

    • Author(s)
      Takamasa Sakai
    • Organizer
      日本化学会春季年会「アジア国際シンポジウム」
    • Related Report
      2009 Final Research Report
  • [Presentation] 均一構造を有するTetra-PEGゲルの構造解析2009

    • Author(s)
      酒井崇匡, 松永拓郎, 柴山充弘, 鄭雄一
    • Organizer
      第20回高分子ゲル研究討論会
    • Place of Presentation
      東京大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] 正四面体様マクロモノマーからなる新規高強度ゲル (Tetra-PEG Gel) の力学物性に及ぼす架橋点間分子量の効果2008

    • Author(s)
      酒井崇匡, 松永拓郎, 赤木友紀, 倉員麻奈実, 柴山充弘, 鄭雄一
    • Organizer
      第57回高分子学会討論会
    • Place of Presentation
      大阪市立大学
    • Related Report
      2009 Final Research Report
  • [Presentation] 四分岐マクロモノマーを用いた高強度ハイドロゲル Tetra-PEG ゲルの創製2008

    • Author(s)
      酒井崇匡
    • Organizer
      東海高分子研究会講演会
    • Related Report
      2009 Final Research Report
  • [Presentation] 正四面体様マクロモノマーからなる新規高強度ゲル(Tetra-PEGゲル)の力学物性に及ぼす架橋点間分子量の効果2008

    • Author(s)
      酒井崇匡, 赤木友紀, 倉員麻奈美, 松永拓郎, 柴山充弘, 鄭雄一
    • Organizer
      第57回高分子学会討論会
    • Place of Presentation
      大阪市立大学
    • Related Report
      2008 Annual Research Report
  • [Book] 生体材料 「ゲルコントロール」2009

    • Author(s)
      酒井崇匡
    • Publisher
      情報機構
    • Related Report
      2009 Final Research Report
  • [Book] 生体適合性を有するインジェクタブル高強度ゲル-Tetra-PEG ゲル 「ゲルコントロール」2009

    • Author(s)
      酒井崇匡
    • Publisher
      情報機構
    • Related Report
      2009 Final Research Report
  • [Book] ゲルコントロール-上手なゲルの作り方とゲル化の抑制-2009

    • Author(s)
      酒井崇匡
    • Total Pages
      13
    • Publisher
      情報機構
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.tetrapod.t.u-tokyo.ac.jp/

    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 特願2008-3243132008

    • Inventor(s)
      酒井崇匡, 等
    • Industrial Property Rights Holder
      ネクスト21, 等
    • Filing Date
      2008-12-19
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 超高強度インジェクタブルハイドロゲル及びその製造方法2008

    • Inventor(s)
      酒井崇匡など
    • Industrial Property Rights Holder
      株式会社ネクスト21など
    • Industrial Property Number
      2008-324313
    • Filing Date
      2008-12-19
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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