Development of artificial peripheral nerve for regenerative medicine

Research Project

Project/Area Number	20860063
Research Category	Grant-in-Aid for Young Scientists (Start-up)
Allocation Type	Single-year Grants
Research Field	Biofunction/Bioprocess
Research Institution	Kyushu University
Principal Investigator	TAKEI Takayuki Kyushu University, 大学院・工学研究院, 助教 (90468059)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,861,000 (Direct Cost: ¥2,970,000、Indirect Cost: ¥891,000) Fiscal Year 2009: ¥1,937,000 (Direct Cost: ¥1,490,000、Indirect Cost: ¥447,000) Fiscal Year 2008: ¥1,924,000 (Direct Cost: ¥1,480,000、Indirect Cost: ¥444,000)
Keywords	末梢神経 / 生体組織工学 / ヒドロゲル / 中空ファイバー / ファイバー / 生体模倣
Research Abstract	Calcium-alginate hollow microfibers with various outer (100-800μm) and inner diameters (inner diameter/outer diameter=0.06-0.80) were successfully fabricated using a spinning system consisted of a triple extrusion head. Stretching the microfibers resulted in decrease in outer diameter of them (less than 100μm). Immobilization of gelatin into the microfibers enhanced adhesion and proliferation of enclosed mammalian cells, such as neuronal cell and glial cell lines.