Molecular evolution of multiplicity of Toll-like receptors in echinoderm genome
| Project/Area Number |
20870007
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Evolutionary biology
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| Research Institution | Saitama University |
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Principal Investigator |
HIBINO Taku Saitama University, 教育学部, 准教授 (60513835)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | Toll-like receptor / ウニ / 棘皮動物 / 自然免疫 / トリノアシ |
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| Research Abstract |
It has been known that approximately 10 Toll-like receptors (TLRs) in the genome of fruit fly and human. On the other hand the genomes of marine invertebrates such as a sea urchin, an amphioxus and a polychaete contain approximately 70 to 200 TLRs forming multigene family. We investigated molecular evolution of TLRs and innate immune related genes between human and fruit fly, and marine invertebrates. Multiplication of IL-17 and Sarm-like gene family that contains an old-TIR domain were found uniquely in these marine invertebrates. Appearance of these gene families may be related to multiplicity of TLRs.
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Report
(3 results)
Research Products
(18 results)
