| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Research Abstract |
It has been known that approximately 10 Toll-like receptors (TLRs) in the genome of fruit fly and human. On the other hand the genomes of marine invertebrates such as a sea urchin, an amphioxus and a polychaete contain approximately 70 to 200 TLRs forming multigene family. We investigated molecular evolution of TLRs and innate immune related genes between human and fruit fly, and marine invertebrates. Multiplication of IL-17 and Sarm-like gene family that contains an old-TIR domain were found uniquely in these marine invertebrates. Appearance of these gene families may be related to multiplicity of TLRs.
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