Research Project
Grant-in-Aid for Young Scientists (Start-up)
Recent genome-wide association studies have linked autophagy, an intracellular bulk degradation system essential for diverse physiological process, with Crohn's disease, a major form of chronic inflammatory bowel disease. Single nucleotide polymorphisms in Atg16L (T300A) is a risk factor for Crohn's disease. However, it has been ill defined how the Atg16L variant confers the development of the disease. We demonstrate that Atg16L is a critical regulator of autophagy responsible for the control of the endotoxin-mediated immune response ; its dysfunction may be associated with inflammatory diseases such as colitis. Furthermore, we provide the first evidence that deletion of WD repeat domain and T300A mutation in Atg16L1 have little impact on canonical autophagy and autophagy against bacteria, Salmonella typhimurium. We therefore propose that Atg16L1 T300A is differentially involved in Crohn's disease and canonical autophagy.
All 2010 2009 2008 Other
All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (2 results) Book (2 results) Remarks (3 results)
Mol Biol Cell (In press)
Cell Microbiol. (In press)
J Biol Chem. 284
Pages: 32602-32609
Proc Natl Acad Sci U S A 106
Pages: 20842-20846
Nature Cell Biology. 11
Pages: 1433-1437
J Biol Chem 284
Nature Cell Biology 11
Proc Natl Acad Sci USA (In press)
Nature. 456
Pages: 264-268
Mol Biol Cell. 19
Pages: 2092-2100
Pages: 2916-2925
Pages: 4651-4659
http://www.saibouseigyo.com/jp/
http://www.biken.osaka-u.ac.jp/act/act_yoshimori.php
