A genetic approach for the neuronal cell fate determination in Drosophila.

• Project/Area Number: 20870034
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Developmental biology
• Research Institution: Keio University
• Principal Investigator: KANDA Hiroshi Keio University, 医学部, 助教 (60508597)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 神経 / スクリーニング / ショウジョウバエ / 遺伝学 / Musashi / SOP

Research Abstract

We have elucidated the molecular basis of how neuronal cell fate is determined by an RNA-binding protein, Musashi, using powerful Drosophila genetics. In this project, we have aimed to identify and analyze up/downstream signal components of Musashi-related cell fate determination.

Research Products

• [Journal Article] Regenerative Growth in Drosophila Imaginal Discs Is Regulated by Wingless and Myc (2009)
  • Author(s): Smith-Bolton R, Worley M, Kanda H, Hariharan IK
  • Journal Title: Dev Cell 16(6) Pages: 797-809
  • Peer Reviewed
• [Presentation] in vivo large scale screen to identify molecules that regulate the integrity of Blood-Brain Barrier in Drosophila (2009)
  • Author(s): 菅田浩司、島村理恵子、岡野栄之
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜・横浜
  • Year and Date: 2009-12-09
• [Presentation] Genetic analysis of the organization and function of the blood-brain barrier in Drosophila (2009)
  • Author(s): 菅田浩司、島村理恵子、岡野栄之
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場・名古屋
  • Year and Date: 2009-09-17
• [Presentation] A genetic approach for the organization and function of blood-brain barrier in Drosophila (2009)
  • Author(s): 菅田浩司、島村理恵子、岡野栄之
  • Organizer: 第9回日本ショウジョウバエ研究会
  • Place of Presentation: ヤマハリゾートつま恋・三島
  • Year and Date: 2009-07-06
• [Presentation] A genetic screen for regulators of cell growth and proliferation (2009)
  • Author(s): Kanda H, Alexander H. Nguyen, Leslie Chen, Iswar K. Hariharan
  • Organizer: 50th Annual Drosophila Research Conference
  • Place of Presentation: Chicago, USA
• [Presentation] A Genetic Screen for Regulators of Cell Growth and Proliferation. (2009)
  • Author(s): Hiroshi Kanda
  • Organizer: 50th Annual Drosophila Research Conference
  • Place of Presentation: アメリカ合衆国・シカゴ
• [Remarks] 慶應義塾大学医学部生理学教室
  • URL: http://www.okano-lab.com/