| Project/Area Number |
20880005
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
General fisheries
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| Research Institution | Tohoku University |
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Principal Investigator |
ITOH Naoki Tohoku University, 大学院・農学研究科, 助教 (30502736)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 生体防御 / パターン認識受容体 / 病原体関連分子パターン / ペプチドグリカン / β-グルカン / 二枚貝 / マガキ / 自然免疫 / βグルカン |
|---|
| Research Abstract |
This research project partially elucidated the mechanisms of pathogen recognitions and early immune responses against recognized pathogens in marine bivalves. Briefly, a marine bivalves, Pacific oyster, possesses various pathogen recognition receptor (PRR) proteins, and starts immune reactions after PRR recognize pathogens. Similar defense manners have been reported from other invertebrates, but some PRR proteins in Pacific oyster have highly characteristic structures. Based on these findings, it is considered that recognition and early immune response in marine bivalves may be similar but not identical to known mechanisms in other invertebrates such as arthropods.
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