Analysis of molecular mechanism underlying highly sensitive detection of sex pheromones in insects.

• Project/Area Number: 20880006
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Applied entomology
• Research Institution: The University of Tokyo
• Principal Investigator: SAKURAI Takeshi The University of Tokyo, 先端科学技術研究センター, 特任助教 (20506761)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 昆虫 / 性フェロモン / 嗅覚 / 分子遺伝学 / 遺伝子

Research Abstract

To elucidate molecular mechanisms underlying highly sensitive detection of sex pheromones in insects, we examined functional roles of sex pheromone receptor proteins, pheromone binding proteins, and sensory neuron membrane protein-1 (SNMP1) in the silkmoth Bombyx mori. We found that the response specificity of pheromone receptor neurons is determined by the response spectrum of the expressed receptor protein. We also found that expression of SNMP1 increases the peak response amplitude of Xenopus oocytes expressing pheromone receptor proteins to pheromone stimulations.

Research Products

• [Journal Article] Understanding and Reconstruction of the Mobiligence of Insects Employing Multi-Scale Biological Approaches and Robotics. (2008)
  • Author(s): Ryohei Kanzaki, Noriyasu Ando, Takeshi Sakurai, Tomoki Kazawa
  • Journal Title: Advanced Robotics 22 Pages: 1605-1628
  • Peer Reviewed
• [Journal Article] Identification of receptors of main sex-pheromone components of three Lepidopteran species. (2008)
  • Author(s): Hidefumi Mitsuno, Takeshi Sakurai, 他
  • Journal Title: European Journal of Neuroscience 28 Pages: 893-902
  • Peer Reviewed
• [Journal Article] Identification of receptors of main sex-pheromone components of three Lepidopteran species (2008)
  • Author(s): Hidefumi Mitsuno
  • Journal Title: European Journal of Neuroscience 28 Pages: 893-902
  • Peer Reviewed
• [Journal Article] Understanding and reconstruction of the mobiligence of insects employing multiscale biological approaches and robotics (2008)
  • Author(s): Ryohei Kanzaki
  • Journal Title: Advanced Robotics 22 Pages: 1605-1628
  • Peer Reviewed
• [Journal Article] A single sex pheromone receptor determines chemical response specificity of sexual behavior in the silkmoth Bombyx mori.
  • Author(s): Takeshi Sakurai, Hidefumi Mitsuno, Stephan Shuichi Haupt, Keiro Uchino, Fumio Yokohari, Takaaki Nishioka, Isao Kobayashi, Hideki Sezutsu, Toshiki Tamura, Ryohei Kanzaki
  • Journal Title: PLoS Genetics (in press)
  • Peer Reviewed
• [Presentation] フェロモン源定位行動発現の匂い特異性を決定する分子・神経基盤 (2011)
  • Author(s): 櫻井健志
  • Organizer: 第55回日本応用動物昆虫学会
  • Place of Presentation: 九州大学,福岡
• [Presentation] カイコガフェロモン源定位行動の発現におけるボンビコール受容細胞の役割 (2010)
  • Author(s): 櫻井健志
  • Organizer: 第5回移動知シンポジウム
  • Place of Presentation: 松島、宮城
• [Presentation] カイコのフェロモン情報処理からバイオロボットへ (2009)
  • Author(s): 櫻井健志
  • Organizer: 天皇陛下御在位20年慶祝行事公開シンポジウム
  • Place of Presentation: つくば国際会議場、茨城
  • Year and Date: 2009-11-18
• [Presentation] 種認識における性フェロモン受容体の役割 (2009)
  • Author(s): 櫻井健志
  • Organizer: 第53回日本応用動物昆虫学会
  • Place of Presentation: 北海道大学,北海道
• [Presentation] 種認識における性フェロモン受容体の役割 (2009)
  • Author(s): 櫻井健志
  • Organizer: 第53回日本応用動物昆虫学会
  • Place of Presentation: 北海道大学・北海道
• [Book] The Neurobiology of Olfaction Frontiers in Neuroscience(ed. Anna Menini) (2009)
  • Author(s): S.Shuichi Haupt, Takeshi Sakurai, Shigehiro Namiki, Tomoki Kazawa, Ryohei Kanzaki
  • Publisher: CRC Press
• [Book] 昆虫の分子生物学-ポストゲノムの昆虫研究-(神村学,日本典秀,葛西真治,竹内秀明,畠山正統,石橋純 編) (2009)
  • Author(s): 櫻井健志
  • Publisher: 共立出版
• [Remarks] ホームページ等
  • URL: http://www.brain.rcast.u-tokyo.ac.jp/
• [Remarks]
  • URL: http://www.brain.imi.i.u-tokyo.ac.jp/