Clinical trial of Spinal Cord Regeneration Treatment by Transplanting Olfactory Ensheathing Cells (OECs) in Dogs

• Project/Area Number: 20880027
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Clinical veterinary science
• Research Institution: Nihon University
• Principal Investigator: ITO Daisuke Nihon University, 生物資源科学部, 助手 (40508694)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 再生医療 / Olfactory Ensheathing Glia(OEG) / 鼻粘膜 / 嗅粘膜 / 脊髄疾患 / 脊髄損傷 / 脊髄再生 / OEG / 椎間板ヘルニア / Olfactory Ensheashing Cells / 脊髄再生医療 / Olfactory Ensheathing Glias

Research Abstract

The purpose of this study was a clinical trial of nasal mucosa derived OECs transplantation therapy to regenerate the function of the spinal cord in the clinical cases of dogs with paraplegia due to spinal cord injury. However I could not apply the therapy to any case because the owner of dogs did not agree with this clinical trial, although there were many dogs which could become candidate. Therefore I established new method to harvest the olfactory mucosa without craniotomy by endoscopic biopsy via nasal cavity. In addition I studied electrophysiological examination using extradural catheter electrode in dogs to select cases for cell transplantation therapy and to decide the efficacy of the therapy.