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Role for autophagy in oxidative stress-induced prematuere senescence in zebrafish models

Research Project

Project/Area Number 20880045
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Fisheries chemistry
Research InstitutionFisheries Research Agency

Principal Investigator

IMAMURA Shintaro  Fisheries Research Agency, 中央水産研究所, 研究員 (80510007)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥1,625,000 (Direct Cost: ¥1,250,000、Indirect Cost: ¥375,000)
Fiscal Year 2009: ¥572,000 (Direct Cost: ¥440,000、Indirect Cost: ¥132,000)
Fiscal Year 2008: ¥1,053,000 (Direct Cost: ¥810,000、Indirect Cost: ¥243,000)
Keywords酸化ストレス / 老化 / タンパク質分解 / オートファジー / ゼブラフィッシュ
Research Abstract

Oxidative stress is important for longevity regulation. Accumulation of oxidized proteins may induce cellular senescence during aging process. Autophagy, bulky protein degradation pathway promoted the degradation of oxidized proteins under oxidative stress condition in fish. Autophagy inhibition was induced premature senescence by oxidative stress. These findings indicate that autophagy is essential to prevent the oxidized proteins and exhibit anti-aging functions in fish models.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (3 results)

All 2010 2009

All Presentation (3 results)

  • [Presentation] 酸化ストレスによって誘導される細胞老化におけるオートファジーの役割2010

    • Author(s)
      今村伸太朗
    • Organizer
      平成22年度日本水産学会春季大会
    • Related Report
      2009 Final Research Report
  • [Presentation] Role for autophagy in oxidative stress-induced prematuere senescence in zebrafish models2009

    • Author(s)
      Shintaro Imamura
    • Organizer
      The 4^<th> International Congress on Stress Responses in Biology and Medicine and The 4^<th> Annual Meeting of the biomedical Society for Stress Response
    • Place of Presentation
      Gateaux kingdom Sapporo Hotel and Spa Resort
    • Year and Date
      2009-10-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role for autophagy in oxidative stress-induced prematuere senescence inzebrafish models2009

    • Author(s)
      Shintaro Imamura
    • Organizer
      The 4th International Congress on Stress Respon ses in Biology and Medicine and The 4th Annual Meeting of the biomedical Society for Stress Response
    • Place of Presentation
      Oral presentation
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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