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Mechanism of Transcriptional and Secretary Regulation in Gut Incretin Producing Cells.

Research Project

Project/Area Number 20890011
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionAsahikawa Medical College

Principal Investigator

FUJITA Yukihiro  Asahikawa Medical College, 医学部, 助教 (20451461)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
Keywordsインクレチン / GIP / GLP-1 / 転写因子 / 小腸糖代謝 / 甘味受容体 / 小腸 / 糖代謝
Research Abstract

Two transcription factors Pdx1 and Pax6 play pivotal roles for GIP gene regulation. Some reports showed that the sweet taste receptor is involved in sugar-induced incretin secretion, however, we indicated that sweeteners, which surly bind to the receptor, do not enhance incretin release in rats.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (10 results)

All 2010 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut.2010

    • Author(s)
      Fujita Y, et al.
    • Journal Title

      American Journal of Physiology(Gastro & Liver) 298(5)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo2009

    • Author(s)
      Fujita Y, Wideman RD, Speck M, Asadi A, King DS, Webber TD, Haneda M, Kieffer TJ.
    • Journal Title

      Am J Physiol Endocrinol Metab 296(3)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo.2009

    • Author(s)
      Fujita Y, et al.
    • Journal Title

      American Journal of Physiology(Endo & Metab) 296(3)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells2008

    • Author(s)
      Fujita Y, Chui JWY, King DS, Zhang T, Seufert J, Pownall S, Cheung AT, Kieffer TJ.
    • Journal Title

      Am J Physiol Endocrinol Metab 295

    • Related Report
      2009 Final Research Report
  • [Journal Article] Pax6 and Pdxl are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells2008

    • Author(s)
      Fujita Y, et.al.
    • Journal Title

      American Journal of Physiology (Endo & Metab) 296(3)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 甘味受容体アゴニストは糖質と異なりGIPおよびGLP-1の分泌を促進しない2009

    • Author(s)
      藤田征弘
    • Organizer
      日本糖尿病学会年次学術総会
    • Place of Presentation
      大阪 国際会議場
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 甘味受容体アゴニストは糖質と異なりGIPおよびGLP-1の分泌を促進しない2009

    • Author(s)
      藤田征弘, Wideman RD, Asadi A, Speck M, 羽田勝計, Kieffer TJ.
    • Organizer
      第52回日本糖尿病学会年次学術総会
    • Place of Presentation
      大阪 国際会議場
    • Related Report
      2009 Final Research Report
  • [Presentation] 転写因子Pax6 とPdx1はともにGLP-1分泌細胞 (L細胞) におけるGIP共発現に重要である2008

    • Author(s)
      藤田征弘, 羽田勝計, Timothy J Kieffer
    • Organizer
      第51回日本糖尿病学会年次学術総会
    • Place of Presentation
      東京 東京フォーラム
    • Related Report
      2009 Final Research Report
  • [Presentation] Incretin Release from Gut is Enhanced by Sugar but Not by Sweeteners In Vivo2008

    • Author(s)
      Fujita Y, Speck S, Asadi A, Webber TD, Kieffer TJ.
    • Organizer
      American Diabetes Association, 68^<th> Scientific Sessions
    • Place of Presentation
      San Francisco, California
    • Related Report
      2009 Final Research Report
  • [Book] 月刊糖尿病 別冊インクレチン ; インクレチンの分泌機構2009

    • Author(s)
      藤田征弘, 羽田勝計
    • Publisher
      医学出版
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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