| Project/Area Number |
20890014
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
ABE Keiko Tohoku University, 大学院・医学系研究科, 助教 (80455782)
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|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 肺癌 / 女性 / アロマターゼ / ホルモン受容体 |
|---|
| Research Abstract |
Highly concordant coexpression of estrogen receptor beta and aromatase, one of the estrogen-producing enzyme, was observed among non-small cell carcinoma of the lung. Pulmonary adenocarcinoma, which is the most frequently observed among Japanese female lung cancer patients, is divided into two categories, such as bronchio-alveolar carcinoma (BAC) and non-BAC. BAC is defined as non-invasive adenocarcinoma by WHO criteria, otherwise non-BAC is invasive carcinoma and has more malignant potential. The co-expression of both aromatase and ER beta was more frequently observed among non-BAC of the lung. Furthermore, the proportion of ER beta in non-BAC of the lung was correlated with the proliferative activity of cancer cells.
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