elucidation of the molecular mechanism of angiogenesis induced by the external shockwaves and its therapeutic application for the treatment of chronic heart failure

• Project/Area Number: 20890016
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Tohoku University
• Principal Investigator: NAKANO Matkoto Tohoku University, 大学院・医学系研究科, 助教 (30513551)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 体外衝撃波治療法 / 血管新生 / 慢性心不全 / 血管内皮前駆細胞

Research Abstract

We demonstrated that shockwave treatment applied to cultured human umbilical vein endothelial cells upregulated mRNA expression of vascular endothelial growth factor, although further studies are required to determine the optimal condition of the shockwave treatment. Extracorporeal shockwave therapy to a rat model of chronic heart failure was performed, which induced a tendency to improve both left ventricular contractile function and survival rate.

Research Products

• [Journal Article] Statin Ameliorates Hypoxia-Induced Pulmonary Hypertension Associated with Down-regulated Stromal Cell-Derived Factor-1 (2009)
  • Author(s): Satoh K, Nakano M, Shimokawa H, et.al.
  • Journal Title: Cardiovascular Research 81 Pages: 226-234
  • Peer Reviewed
• [Journal Article] Spatial Non-uniformity of Excitation-Contraction Coupling Can Enhance Arrhythmogenic Delayed Afterdepolarizations in Rat Cardiac Muscle (2008)
  • Author(s): Miura M, Nakano M, Shimokawa H, et.al.
  • Journal Title: Cardiovascular Research 80 Pages: 55-61
  • Peer Reviewed
• [Presentation] Differential Roles of Progenitor Cells in Cardiovascular Disease (2009)
  • Author(s): 中野誠, 下川宏明, 他
  • Organizer: 日本循環器学会
  • Place of Presentation: リーガロイヤルホテル大阪
  • Year and Date: 2009-03-20
• [Presentation] Genetic Deletion of OX40 Ligand Suppresses the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice (2009)
  • Author(s): 中野誠, 下川宏明, 他
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-03-20
• [Presentation] Genetic Deletion of OX40 Ligand Suppresses the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice (2009)
  • Author(s): 中野誠, 下川宏明, 他
  • Organizer: 日本心脈管作動物質学会
  • Place of Presentation: 岡山大学50周年記念講堂
  • Year and Date: 2009-02-06
• [Remarks] 東北大学循環器内科ホームページ
  • URL: http://www.cardio.med.tohoku.ac.jp/index.html