| Project/Area Number |
20890017
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Infectious disease medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
YAMAMOTO Natsuo Tohoku University, 大学病院, 助教 (50466562)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 肺炎球菌性急性肺炎 / B-1B細胞 / activation-induced cytidine deaminase (AID) / 抗ホスホリルコリンIgM抗体 / iNKT細胞 / 接触性過敏反応(Contact Sensitivity ; CS) / ELISPOTアッセイ / Interleukin(IL)-13 / B-1細胞 / activation-induced cytidine deaminase(AID) / 接触性過敏反応(CS) / Interleukin (IL)-13 |
|---|
| Research Abstract |
B-1B cells were rapidly activated by an acute lung infection with a crucial involvement of iNKT cells upstream. B-1B cells then migrate to the spleen where an increase of B-1B cell numbers were shown by the measurements of ELISPOT assay for anti-phosphorylcholine IgM producing cells. Further, the activated B-1B cells acted more protectively with utilizing activation-induced cytidine deaminase (AID) within 2 days post airway infection than their naive status.
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