Therapeutic efficacy by adoptive transfer of iNKT cells and B-1Bcells to severe acute bacterial pneumonia
Project/Area Number |
20890017
|
Research Category |
Grant-in-Aid for Young Scientists (Start-up)
|
Allocation Type | Single-year Grants |
Research Field |
Infectious disease medicine
|
Research Institution | Tohoku University |
Principal Investigator |
YAMAMOTO Natsuo Tohoku University, 大学病院, 助教 (50466562)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
|
Keywords | 肺炎球菌性急性肺炎 / B-1B細胞 / activation-induced cytidine deaminase (AID) / 抗ホスホリルコリンIgM抗体 / iNKT細胞 / 接触性過敏反応(Contact Sensitivity ; CS) / ELISPOTアッセイ / Interleukin(IL)-13 / B-1細胞 / activation-induced cytidine deaminase(AID) / 接触性過敏反応(CS) / Interleukin (IL)-13 |
Research Abstract |
B-1B cells were rapidly activated by an acute lung infection with a crucial involvement of iNKT cells upstream. B-1B cells then migrate to the spleen where an increase of B-1B cell numbers were shown by the measurements of ELISPOT assay for anti-phosphorylcholine IgM producing cells. Further, the activated B-1B cells acted more protectively with utilizing activation-induced cytidine deaminase (AID) within 2 days post airway infection than their naive status.
|
Report
(3 results)
Research Products
(16 results)
-
-
-
-
[Presentation] IL-13 Dependent Early Protective Role of B-1 Cell Function in Acute Bacterial Pneumonia2009
Author(s)
Yamamoto N, Steven KM, Aoyagi T, Hatta M, Kunishima H, Miyazato A, Hirakata Y, Kawakami K, Kaku M, Askenase PW, et al.
Organizer
第49回日本呼吸器学会学術講演会
Place of Presentation
東京国際フォーラム
Year and Date
2009-06-12
Related Report
-
[Presentation] IL-13 Dependent Early Protective Role of B-1 Cell Function in Acute Bacterial Pneumonia.2009
Author(s)
Yamamoto N, Steven KM, Aoyagi T, Hatta M, Kunishima H, Miyazato A, Hirakata Y, Kawakami K, Kaku M, Askenase PW, et al.
Organizer
第49回日本呼吸器学会学術講演会
Place of Presentation
東京国際フォーラム(東京都)
Year and Date
2009-06-12
Related Report
-
-
-
-
-
-
-
-
-
-
-