Mechanisms of mechanical response in bony tissues derived from CCN2 deficient mice.
| Project/Area Number |
20890024
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
KAWAKI Harumi Tohoku University, 大学院・歯学研究科, 助教 (70513670)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | CCNファミリー / CTGF / ノックアウトマウス / 骨芽細胞 / 骨細胞 / 軟骨細胞 / メカニカルストレス / 骨リモデリング / メカニカルストレス応答 / CCN family / CCN2 / 細胞小器官 |
|---|
| Research Abstract |
(1) The lack of CCN2 caused up-regulation of CCN3 in CCN2-null mice, which resulted in the observed phenotypes, such as the resultant delay of terminal differentiation. The involvement of the PTHrP-Ihh loop in the regulation of CCN3 expression is also suggested. (Kawaki et al., JBMR 2008.)
(2) We investigated the expression of CCN family members and their functions osteoblast differentiation. Results showed that CCN members were differentially expressed and therefore could participate in osteoblast lineage progression. (manuscript in preparation.)
(3) We found that the stability of human ccn4 mRNA was regulated by its 3'UTR region. (manuscript in preparation.)
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin suggests abnormal palate development after palatal fusion2010
Author(s)
Imura H, Yamada T, Mishima K, Fujiwara K, Kawaki H, Hirata A, Sogawa N, Ueno T, Sugahara T.
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Journal Title
Congenit Anom (Kyoto) (印刷中)
Related Report
Peer Reviewed
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[Journal Article] Thrombopoietic-mesenchymal interaction that may facilitate both endochondral ossification and platelet maturation via CCN2.2010
Author(s)
Sumiyoshi K, Kubota S, Furuta RA, Yasui K, Aoyama E, Kawaki H, Kawata K, Ohgawara T, Yamashiro T, Takigawa M.
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Journal Title
J Cell Commun Signal. (未定, accepted)
Related Report
Peer Reviewed
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[Journal Article] Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin suggests abnormal palate development after palatal fusion.2010
Author(s)
Imura H, Yamada T, Mishima K, Fujiwara K, Kawaki H, Hirata A, Sogawa N, Ueno T, Sugahara T.
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Journal Title
Congenit Anom (Kyoto). (未定, accepted)
Related Report
Peer Reviewed
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[Journal Article] Increased expression of matrilin-3 not only in osteoarthritic articular cartilage but also in cartilage-forming tumors, and down-regulation of SOX9 via epidermal growth factor domain 1-dependent signaling2008
Author(s)
Vincourt JB, Vignaud JM, Lionneton F, Sirveaux F, Kawaki H, Marchal S, Lomazzi S, Plenat F, Guillemin F, Netter P, Takigawa M, Mainard D, Magdalou J.
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Journal Title
Arthritis Rheum. 58巻
Pages: 2798-2808
Related Report
Peer Reviewed
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[Journal Article] Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage2008
Author(s)
Kawaki H, Kubota S, Suzuki A, Lazar N, Yamada T, Matsumura T, Ohgawara T, Maeda T, Perbal B, Lyons KM, Takigawa M.
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Journal Title
J Bone Miner Res. 23巻
Pages: 1751-1764
Related Report
Peer Reviewed
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[Journal Article] Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN22008
Author(s)
Ono M, Kubota S, Fujisawa T, Sonoyama W, Kawaki H, Akiyama K, Shimono K, Oshima M, Nishida T, Yoshida Y, Suzuki K, Takigawa M, Kuboki T.
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Journal Title
Cell Transplant 17巻
Pages: 231-240
Related Report
Peer Reviewed
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