The role of inhibitory receptor MAIR-I in innate immunity
| Project/Area Number |
20890027
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
ODA Chigusa University of Tsukuba, 大学院・人間総合科学研究科, 研究員 (50510054)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥2,418,000 (Direct Cost: ¥1,860,000、Indirect Cost: ¥558,000)
Fiscal Year 2009: ¥1,248,000 (Direct Cost: ¥960,000、Indirect Cost: ¥288,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 炎症 / 敗血症 / MAIR-I / 抑制性レセプター / 自然免疫 |
|---|
| Research Abstract |
Myeloid-associated immunoglobulin-like receptor (MAIR)-I is expressed on most myeloid lineage cells and regulates the activation of these cells. Here we showed that decreased mortality in MAIR-I-deficient mice with experimental peritonitis-sepsis. Because sepsis is the systemic inflammatory syndrome induced by severe infections, remains a leading cause of death worldwide, these results suggest that MAIR-I is a novel molecular target for the treatment of sepsis.
|
Report
(3 results)
Research Products
(3 results)
