The role of inhibitory receptor MAIR-I in innate immunity

Research Project

Project/Area Number	20890027
Research Category	Grant-in-Aid for Young Scientists (Start-up)
Allocation Type	Single-year Grants
Research Field	Immunology
Research Institution	University of Tsukuba
Principal Investigator	ODA Chigusa University of Tsukuba, 大学院・人間総合科学研究科, 研究員 (50510054)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥2,418,000 (Direct Cost: ¥1,860,000、Indirect Cost: ¥558,000) Fiscal Year 2009: ¥1,248,000 (Direct Cost: ¥960,000、Indirect Cost: ¥288,000) Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	炎症 / 敗血症 / MAIR-I / 抑制性レセプター / 自然免疫
Research Abstract	Myeloid-associated immunoglobulin-like receptor (MAIR)-I is expressed on most myeloid lineage cells and regulates the activation of these cells. Here we showed that decreased mortality in MAIR-I-deficient mice with experimental peritonitis-sepsis. Because sepsis is the systemic inflammatory syndrome induced by severe infections, remains a leading cause of death worldwide, these results suggest that MAIR-I is a novel molecular target for the treatment of sepsis.

Report

(3 results)