| Project/Area Number |
20890030
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KAI Hirayasu University of Tsukuba, 大学院・人間総合科学研究科, 講師 (60510138)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 急速進行性糸球体腎炎 / DNAM-1(CD226) / 抗糸球体基底膜抗体型糸球体腎炎 / 半月体形成糸球体腎炎 / DNAM-1遺伝子欠損マウス / anti-GBM型糸球体腎炎 / DNAM-1 / anti-GBM抗体 |
|---|
| Research Abstract |
DNAM-1 (CD226) is an adhesion molecule expressed on the majority of NK cells, T cells, monocytes and platelets and physically and functionally associates with leukocyte function-associated antigen-1 (LFA-1). The poliovirus receptor (PVR) CD155 and its family member CD112 (PVR-related family-2 (PRR-2), also called as nectin-2) are ligands for human and mouse DNAM-1. We analyzed rapid progressive glomerulonephritis for wild type mouse and DNAM-1 (CD226) gene deficit mouse using antiglomerulus basement membrane antibody. We compared wild type mouse with the DNAM-1 gene deficit mouse, and the degree of the nephritis was showed weakly. The possibility that DNAM-1 related with the onset of the rapid progressive glomerulonephritis was suggested.
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