morphologic and epigenetic study on the effects of child abuse on brain development

• Project/Area Number: 20890033
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Legal medicine
• Research Institution: Gunma University (2009); University of Toyama (2008)
• Principal Investigator: SANO Rie Gunma University, 大学院・医学系研究科, 助教 (70455955)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥1,664,000 (Direct Cost: ¥1,280,000、Indirect Cost: ¥384,000); Fiscal Year 2009: ¥156,000 (Direct Cost: ¥120,000、Indirect Cost: ¥36,000); Fiscal Year 2008: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
• Keywords: 子どもの虐待 / DNAメチル化 / エピジェネティック / 虐待 / 小児 / 脳

Research Abstract

To investigate the effect on the brain of child abuse, we studied whether childhood abuse alters pattern of DNA methylation of genes. We examined Age-dependent DNA methylation of genes by Pyrosequencing method and compared with child abuse victim.

Research Products

• [Journal Article] A fatal case of myocardial damage due to misuse of the "designer drug" (2009)
  • Author(s): Sano R, Hasuike T, Nakano M, Kominato Y, Itoh H
  • Journal Title: MDMA.Legal Med 11(6) Pages: 294-297
  • Peer Reviewed
• [Journal Article] A case of acute myocardial infarction after intracoronary stent implantation : demonstration of the stent location by postmortem X-ray examination (2009)
  • Author(s): Tajima Y, Takagi R, Kominato Y.
  • Journal Title: Legal Med 11 Pages: 226-228
  • Peer Reviewed
• [Journal Article] Development of a Sensitive Enzyme-Linked Immunosorbent Assay for Measurement of DNase I in Human Serum (2009)
  • Author(s): Nakajima T, Takagi-R, Tajima Y, Makita C, Kominato Y, Kuribara J, Ohshima S, Tada H, Tsurugaya H, Kobayashi Y, Takeshita H, Kawai Y, Yasuda T.
  • Journal Title: Clinica Chimica Acta 403 Pages: 219-222
  • Peer Reviewed
• [Journal Article] 11-Tungstophosphate with iron(II) and hydrogen peroxide efficiently detached bacterial biofilm (2009)
  • Author(s): Tajima Y, Takagi R, Nakajima T, Yasuda T, Kominato Y.
  • Journal Title: Biol Pharm Bull. 32 Pages: 1783-1789
  • Peer Reviewed
• [Journal Article] Development of a Sensitive Enzyme-Linked Immunosorbent Assay for Measurement of Dnase I in Human Serum. (2009)
  • Author(s): Nakajima T, 他
  • Journal Title: Clinica Chimica Acta 403 Pages: 219-222
  • Peer Reviewed
• [Journal Article] 11-Tungstophosphate with iron(II)and hydrogen peroxide efficiently detached bacterial biofilm. (2009)
  • Author(s): Tajima Y, 他
  • Journal Title: Biol Pharm Bull. 32 Pages: 1783-1789
  • Peer Reviewed
• [Journal Article] A case of acute myocardial infarction after intracoronary stent implantation : demonstration of the stent location by postmortem X-ray examination. (2009)
  • Author(s): Tajima Y, 他
  • Journal Title: Legal Med 11 Pages: 226-228
  • Peer Reviewed
• [Journal Article] A fatal case of myocardial damage due to misuse of the"designer drug"MDMA. (2009)
  • Author(s): Sano R, 他
  • Journal Title: Legal Med 11 Pages: 294-297
  • Peer Reviewed
• [Journal Article] 核酸分解酵素DNaseI遺伝子の転写調節機構の解明. (2009)
  • Author(s): 高木利恵, 他
  • Journal Title: DNA多型. 17 Pages: 177-179
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 中島たみ子, 他
  • Journal Title: DNA分解酵素I(日本臨床) Pages: 546-549
• [Journal Article] Development of a sensitive enzyme-linked immunosorbent assay for measurement of DNase I in human serum. (2009)
  • Author(s): Nakajima T, Takagi R, Tajima Y, Makita C, Kominato Y, Kuribara J, Ohshima S, Tada H, Tsurugaya H, Kobayashi Y, Takeshita H, Kawai Y, Yasuda T.
  • Journal Title: Clin Chim Acta. (in press)
  • Peer Reviewed
• [Journal Article] An infant with asymptomatic hepatic granuloma probably caused by bacillus Calmette-Guerin (BCG) vaccination found incidentally at autopsy : a case report (2008)
  • Author(s): Tajima Y, Takagi R, Nakajima T, Kominato Y.
  • Journal Title: Cases J. 1:337 Pages: 1-5
  • Peer Reviewed
• [Journal Article] An infant with asymptomatic hepatic granuloma probably caused by bacillus Calmette-Guerin (BCG) vaccination found incidentally at autopsy: a case report. (2008)
  • Author(s): Tajima Y, Takagi R, Nakajima T, Kominato Y.
  • Journal Title: Cases J 1:337 Pages: 1-5
  • Peer Reviewed
• [Presentation] 群馬大学におけるAiの実際-死後画像と剖検情報の比較融合- (2009)
  • Author(s): 佐野利恵, 粟田さちこ
  • Organizer: 平成21年度群馬県警察医会講演会
  • Place of Presentation: 群馬
  • Year and Date: 2009-10-17
• [Presentation] 低酵素による核酸分解酵素DNASE 1遺伝子の発現増加と転写. (2009)
  • Author(s): 小湊慶彦, 他
  • Organizer: 第93次日本法医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-25
• [Presentation] 低酸素による核酸分解酵素DNASEI遺伝子の転写調節 (2009)
  • Author(s): 佐野利恵, 中島たみ子, 小湊慶彦, 加藤恵理子, 高士祐一, 山根庸弘, 新田みなみ, 藤原純子, 竹下治男, 植木美鈴, 安田年博
  • Organizer: 日本DNA多型学会第18回学術集会
  • Place of Presentation: 久留米
• [Presentation] 死後のCT撮影により過去の受傷痕を証明し得た暴行死の一例 (2009)
  • Author(s): 田島裕, 高木利恵, 小湊慶彦
  • Organizer: 第93次日本法医学会総会
  • Place of Presentation: 大阪
• [Presentation] 低酸素による核酸分解酵素DNASE 1遺伝子の発現増加と転写 (2009)
  • Author(s): 小湊慶彦, 佐野利恵, 中島たみ子, 田島裕, 藤原純子, 竹下治男, 飯田礼子, 安田年博
  • Organizer: 第93次日本法医学会総会
  • Place of Presentation: 大阪
• [Presentation] 死後の単純X線撮影によりステント留置部位を特定し得た急性心筋梗塞の一例 (2008)
  • Author(s): 田島裕, 高木利恵, 小湊慶彦
  • Organizer: 第77回日本法医学会関東地方会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-01
• [Presentation] 核酸分解酵素DNASEI遺伝子の転写調節機構の解明 (2008)
  • Author(s): 小湊慶彦,中島たみ子,田島裕,高木利恵,竹下治男,藤原純子,飯田礼子,安田年博
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-24
• [Presentation] 急死した乳児の肝臓に類上皮結節が見られた一例 (2008)
  • Author(s): 田島裕,高木利恵,小湊慶彦
  • Organizer: 第92次目本法医学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-24
• [Presentation] 核酸分解酵素DNase I遺伝子の転 写調節機構の解明 (2008)
  • Author(s): 高木利恵, 中島たみ子, 小湊慶彦, 加藤恵理子, 高士祐一, 山根庸弘, 新田みなみ, 藤原純子, 竹下治男, 植木美鈴, 安田年博
  • Organizer: 日本DNA多型学会第17回学術集会
  • Place of Presentation: 東京
• [Presentation] 核酸分解酵素DNASE 1遺伝子の転写調節機構の解明 (2008)
  • Author(s): 小湊慶彦, 中島たみ子, 田島裕, 高木利恵, 竹下治男, 藤原純子, 飯田礼子, 安田年博
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎
• [Presentation] 急死した乳児の肝臓に類上皮結節が見られた一例 (2008)
  • Author(s): 田島裕, 高木利恵, 小湊慶彦
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎
• [Presentation] 核酸分解酵素DNaseI遺伝子の転写調節機構の解明 (2008)
  • Author(s): 高木利恵,中島たみ子,小湊慶彦,加藤恵理子,高士祐一,山根庸弘,新田みなみ,藤原純子,竹下治男,植木美鈴,安田年博
  • Organizer: 日本DNA多型学会第17回学術集会
  • Place of Presentation: 東京
• [Book] DNA分解酵素I. (2009)
  • Author(s): 中島たみ子, 佐野利恵, 小湊慶彦, 安田年博
  • Publisher: 日本臨床