Anti-tumor effect of connexin gene for cancer therapy
Project/Area Number |
20890036
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Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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Allocation Type | Single-year Grants |
Research Field |
Medical pharmacy
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Research Institution | Chiba University |
Principal Investigator |
SATO Hiromi Chiba University, 大学院・薬学研究院, 助教 (30506887)
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Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
|
Keywords | がん / 薬学 / エピジェネティック / 薬剤感受性 / 併用効果 / コネキシン遺伝子 / 脱メチル化薬 / 遺伝子 / 癌 |
Research Abstract |
We have investigated the anti-tumor effect of connexin (Cx) gene, component of intercellular gap junction. Finally 5-aza-2'-deoxyxytidine could induce Cx32 expression in renal cell carcinoma, which exerted not only anti-proliferative effect but also improvement of chemotherapeutic cytotoxicity. On the other hands, Cx43 was found to enhance cisplatin cytotoxicity against mesothelioma. Above all, Cx could be useful for treatment of refractory cancers.
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Report
(3 results)
Research Products
(35 results)
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[Presentation] Improvement of sensitivity to vinblastine by restoration of connexin 32 gene in renal cell carcinoma cells2009
Author(s)
Yasuyuki Takano, Hiroki Iwata, Hiromi Sato, Hiroko Okuzawa, Ryota Yamada, Yoji Nagashima, Katsunori Yamaura, Koichi Ueno, Tomohiro Yano
Organizer
米国癌学会議 (AACR) 100^<th> Annual Meeting
Place of Presentation
Denver, CO, USA
Year and Date
2009-04-19
Related Report
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[Presentation] Improvement of sensitivity to vinblastine by restoration of connexin 32 gene in renal cell carcinoma cells2009
Author(s)
Yasuyuki Takano, Hiroki Iwata, Hiromi Sato, Hiroko Okuzawa, Ryota Yamada, Yoji Nagashima, Katsunori Yamaura, Koichi Ueno, Tomohiro Yano
Organizer
米国癌学会(AACR)100^<th> Annual meeting
Place of Presentation
Denver, CO, USA
Year and Date
2009-04-19
Related Report
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