Regulation of memory Th2 cell with NKT cell

• Project/Area Number: 20890038
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Chiba University
• Principal Investigator: IWAMURA Chiaki Chiba University, 大学院・医学研究院, 助教 (10513062)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 免疫学 / アレルギー・ぜんそく

Research Abstract

We found that the number of memory CD4 T cell increased with the activation of NKT cells. And this proliferation was induced by IL-2 produced from activated NKT cell. Furthermore, the activation of NKT cells changed the cytokine productivity of memory Th2 cells, then it could attenuated the memory Th2 cell-dependent allergy airway inflammation. Therefore, the activation of NKT cell can regulate the number and the function of memory CD4 T cells.

Research Products

• [Journal Article] Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung (2010)
  • Author(s): Suzuki, A., Iwamura, C., Shinoda, K., Tumes, J. D., Kimura, Y. M., Hosokawa, H., Endo, Y., Horiuchi, S., Tokoyoda, K., Koseki, H., Yamashita, M., Nakayama, T.
  • Journal Title: J.Immunol. 184 Pages: 4510-4520
  • Peer Reviewed
• [Journal Article] Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells (2010)
  • Author(s): Iwamura, C., Shinoda, K., Yoshimura, M., Watanabe, Y., Obata, A., Nakayama, T.
  • Journal Title: Allergology International. 59 Pages: 67-73
  • NAID: 10029669584
  • Peer Reviewed
• [Journal Article] Polycomb group gene product Ring 1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung. (2010)
  • Author(s): Suzuki, A.
  • Journal Title: J.Immunol. (In press)
  • Peer Reviewed
• [Journal Article] Naringen chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. (2010)
  • Author(s): Iwamura, C
  • Journal Title: Allergol.Int. 59 Pages: 67-73
  • Peer Reviewed
• [Journal Article] CD69 controls the pathogenesis of allergic airway inflammation (2009)
  • Author(s): Miki, H. T., Hasegawa, A., Iwamura, C., Shinoda, K., Tofukuji, S., Watanabe, Y., Hosokawa, H., Motohashi, S., Hashimoto, K., Shirai, M., Yamashita, M., Nakayama, T.
  • Journal Title: J.Immunol. 183 Pages: 8203-8215
  • Peer Reviewed
• [Journal Article] Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice (2009)
  • Author(s): Kitajima, M., Iwamura, C., Miki, H. T., Shinoda, K., Endo, Y., Watanabe, Y., Shinnakasu, R., Hosokawa, H., Kitajima, M., Iwamura, C., Miki, H. T., Shinoda, K., Endo, Y., Watanabe, Y., Shinnakasu, R., Hosokawa, H., Hashimoto, K., Motohashi, S., Koseki, H., Ohara, O., Yamashita, M., Nakayama, T.
  • Journal Title: J.Immunol. 183 Pages: 5388-5396
  • Peer Reviewed
• [Journal Article] CD69 controls the pathogenesis of allergic airway inflammation. (2009)
  • Author(s): Miki, H.T.
  • Journal Title: J.Immunol. 183 Pages: 8203-8215
  • Peer Reviewed
• [Journal Article] Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice. (2009)
  • Author(s): Kitajima, M.
  • Journal Title: J.Immunol. 183 Pages: 5388-5396
  • Peer Reviewed
• [Journal Article] A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity (2008)
  • Author(s): Terashima, A., Watarai, H., Inoue, S., Sekine, E., Nakagawa, R., Hase, K., Iwamura, C., Nakajima, H., Nakayama, T., Taniguchi, M.
  • Journal Title: J.Exp.Med. 205 Pages: 2727-2733
  • Peer Reviewed
• [Journal Article] Repressor of GATA regulates T_H2-driven allergic airway inflammation and airway hyperresponsiveness (2008)
  • Author(s): Hirahara, K., Yamashita, M., Iwamura, C., Shinoda, K., Hasegawa, A., Yoshizawa, H., Koseki, H., Gejyo, F., Nakayama, T.
  • Journal Title: J.Allergy Clin.Immunol. 122 Pages: 512-520
  • Peer Reviewed
• [Journal Article] A novel subset of mouse NKT cells bearing the IL-17 receptor Bresponds to IL-25 and contributes to airway hyperreactivity. (2008)
  • Author(s): Terashima, A.
  • Journal Title: J. Exp. Med. 205 Pages: 2727-2733
  • Peer Reviewed
• [Journal Article] Repressor of GATA regulates TH2-driven allergic airway inflammation and airway hyperresponsiveness. (2008)
  • Author(s): Hirahara, K.
  • Journal Title: J. Allergy Clin. Immunol. 112 Pages: 512-520
  • Peer Reviewed
• [Presentation] Zfp35欠損マウスにおけるTh2細胞分化とアレルギー性気道炎症反応の亢進 (2009)
  • Author(s): 岩村千秋
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] Zfp35欠損マウスにおけるTh2細胞分化とアレルギー性気道炎症反応の亢進 (2009)
  • Author(s): 岩村千秋
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] Sox4 はGATA3によって誘導されるTh2細胞分化およびTh2型炎症反応を制御する (2009)
  • Author(s): 桑原誠, 岩村千秋
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] Sox4はGATA3によって誘導されるTh2細胞分化およびTh2型炎症反応を制御する (2009)
  • Author(s): 桑原誠
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] アポリポタンパクA-IIはCD4 T細胞の活性化を制御することで、ConA 誘導肝炎に対し、保護効果を示す (2009)
  • Author(s): 山下潤二, 岩村千秋
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] アポリポタンパクA-IIはCD4 T細胞の活性化を制御することで、ConA誘導肝炎に対し、保護効果を示す (2009)
  • Author(s): 山下潤二
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] Enhanced Th2 cells differentiation and allergen-induced airway inflammation in Zfp35-deficient mice (2009)
  • Author(s): Iwamura Chiaki
  • Organizer: International congress of mucosal immunology
  • Place of Presentation: Boston, USA
  • Year and Date: 2009-07-06
• [Presentation] 喘息発症に関与するIL-17 RB陽性NKT細胞のサブセット/A novel subset of mouse iNKT cell bearing IL-17 receptor B responsible for the development of asthma (2008)
  • Author(s): Terashima, A., Iwamura Chiaki
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] Crucial role for CD69 in the pathogenesis of Th2-deriven allergic airway inflammation (2008)
  • Author(s): Iwamura, C.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] Polycomb group protein Ring1B regulates Th2-dependent airway inflammation through the control of Th2 cell differentiation andapoptosis (2008)
  • Author(s): Suzuki, A., Iwamura Chiaki
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] 喘息発症関与るIL-17RB陽性NKT細胞のサブヤット/A novel subset of mouse iNKT cell bearing IL-17receptor B responsible for the development of asthma. (2008)
  • Author(s): Terashima, A.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Crucial role for CD69 in the pathogenesis of Th2-derivenallergic airway inflammation. (2008)
  • Author(s): Iwamura, C.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Polycomb group protein RinglB regulates Th2-dependent airway inflammation through the control of Th2 cell differentiation and apoptosis. (2008)
  • Author(s): Suzuki, A.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都