Analysis of role of periostin in cerebral function

• Project/Area Number: 20890046
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: The University of Tokyo
• Principal Investigator: KOIBUCHI Nobutaka The University of Tokyo, 医学部・附属病院, 特任助教 (30456131)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: ペリオスチン / 脳梗塞 / 保護作用 / 神経突起作用 / 中枢神経系

Research Abstract

Periostin is an extracellular matrix protein that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Recently, it was shown that periostin promotes cardiac repair and remodeling. However, it is unclear that periostin plays a role in improvement of cerebral function. Thus, we examined whether periostin promotes cerebral repair.

Research Products

• [Journal Article] Hepatocyte growth factor, but not vascular endothelial growth factor, attenuated angiotensin II-induced EPC senescence (2009)
  • Author(s): Sanada F, Taniyama Y, Azuma J, Iekushi K, Dosaka N, Yokoi T, Koibuchi N, Kusunoki H, Aizawa Y, Morishita R.
  • Journal Title: Hypertension 53 Pages: 77-82
  • Peer Reviewed
• [Journal Article] Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis (2009)
  • Author(s): Mori M, Nakagami H, Koibuchi N, Miura K, Takami Y, Koriyama H, Hayashi H, Sabe H, Mochizuki N, Morishita R, Kaneda Y.
  • Journal Title: Mol. Biol. Cell 20 Pages: 3115-3124
  • Peer Reviewed
• [Journal Article] Negative Action of Hepatocyte Growth Factor/c-Met System on Angiotensin II Signaling via Ligand-Dependent Epithelial Growth Factor Receptor Degradation Mechanism in Vascular Smooth Muscle Cells (2009)
  • Author(s): Sanada F, Taniyama Y, Iekushi K, Azuma J, Okayama K, Kusunoki H, Koibuchi N, Doi T, Aizawa Y, Morishita R.
  • Journal Title: Circ. Res 105 Pages: 667-675
  • Peer Reviewed
• [Journal Article] Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis. (2009)
  • Author(s): Mori M, Nakagami H, Koibuchi N, Miura K, Takami Y, Koriyama H, Hayashi H, Sabe H, Mochizuki N, Morishita R, Kaneda Y.
  • Journal Title: Mol.Biol.Cell. 20 Pages: 3115-3124
  • Peer Reviewed
• [Journal Article] Negative Action of Hepatocyte Growth Factor/c-Met System on Angiotensin II Signaling via Ligand-Dependent Epithelial Growth Factor Receptor Degradation Mechanism in Vascular Smooth Muscle Cells. (2009)
  • Author(s): Sanada F, Taniyama Y, Iekushi K, Azuma J, Okayama K, Kusunoki H, Koibuchi N, Doi T, Aizawa Y, Morishita R.
  • Journal Title: Circ.Res. 105 Pages: 667-675
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor, but not vascular endothelial growth factor, attenuated angiotensin II-induced EPC senescence. (2009)
  • Author(s): Sanada F, Taniyama Y, Azuma J, Iekushi K, Dosaka N, Yokoi T, Koibuchi N, Kusunoki H, Aizawa Y, Morishita R.
  • Journal Title: Hypertension 53 Pages: 77-82
  • Peer Reviewed
• [Journal Article] A Model of Cerebrovasucular Injury in Rats (2008)
  • Author(s): Wakayama K, Shimamura M, Sata M, Koibuchi N, Sato N, Ogihara T, Morishita R.
  • Journal Title: J. Neuroscience Methods 175 Pages: 187-195
  • Peer Reviewed
• [Journal Article] A Model of Cerebrovasucular Injury in Rats. (2008)
  • Author(s): Wakayama K, Shimamura M, Sata M, Koibuchi N. Sato N, Ogihara T, Morishita R.
  • Journal Title: J. Neuroscience Methods. 175 Pages: 187-195
  • Peer Reviewed
• [Presentation] Hepatocyte growth factor (HGF), but not vascular endothelial growth factor (VEGF), attenuated angiotensin II-induced EC senescence by inhibiting PIP3/raclactivity. (2009)
  • Author(s): Sanada F, Taniyama Y, Iekushi K, Dosaka N, Azuma J, Kusunoki H, Koibuchi N, Aizawa Y, Morishita R.
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-22