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TGF-beta decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells

Research Project

Project/Area Number 20890049
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionThe University of Tokyo

Principal Investigator

EHATA Shogo  The University of Tokyo, 大学院・医学系研究科, 助教 (90506726)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,016,000 (Direct Cost: ¥2,320,000、Indirect Cost: ¥696,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,456,000 (Direct Cost: ¥1,120,000、Indirect Cost: ¥336,000)
Keywords遺伝子 / 癌 / シグナル伝達 / 病理学 / 薬剤反応性
Research Abstract

Stem cells in normal tissues and cancer-initiating cells (CICs) are known to be enriched in Side Population (SP) cells. However, the factors responsible for the regulation of expression of ABCG2, involved in efflux of dyes, in SP cells have not been fully investigated. Here, we characterized the SP cells within diffuse-type gastric carcinoma, and examined the effects of TGF-beta on SP cells.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (3 results)

All 2009 Other

All Presentation (2 results) Remarks (1 results)

  • [Presentation] TGF-β diminishes the SP fraction of the diffuse-type gastric cancer cells2009

    • Author(s)
      Shogo Ehata, Ryohei Katayama, Sumie Koike, Yukari Hoshino, Yoko Katsuno, Mitsunobu Kano, Masakazu Yashiro, Kosei Hirakawa, Hiroyuki Aburatani, Naoya Fujita, Kohei Miyazono
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      神奈川県横浜市パシフィコ横浜
    • Year and Date
      2009-10-02
    • Related Report
      2009 Final Research Report
  • [Presentation] TGF-β diminishes the SP fraction of the diffuse-type gastric cancer cells.2009

    • Author(s)
      江幡正悟
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Remarks] 東京大学・大学院医学系研究科・病因病理学専攻・分子病理学分野ホームページ

    • URL

      http://beta-lab.umin.ac.jp/

    • Related Report
      2009 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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