| Project/Area Number |
20890058
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKEMURA Yuri The University of Tokyo, 医学部・附属病院, 助教 (00453697)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 子宮内膜 / 子宮内膜症 / AMPキナーゼ / AMPキサーゼ |
|---|
| Research Abstract |
AMP kinase (AMPK), a regulator of energy homeostasis of the cell, has anti-inflammatory effects with AMPK phosphorylation of endometrial cells, and I surmised that AMPK was involved in implantation and endometriosis. I detected the increased expression of AMPK in the human endometrium in the implantation period and the decreased expression of AMPK in the endometrium of infertile women, suggesting that AMPK may play a physiological role in the implantation. Contrary to conventional hormonal anti-endometriotic drugs that unavoidably suppress estrogen and ovulation, the present study suggest a unique therapeutic potential for metformin as an anti-endometriotic drug.
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