Role of Maf in osteoblast and adipocytes differentiation

• Project/Area Number: 20890060
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: NISIKAWA Keizo Tokyo Medical and Dental University, 医歯学総合研究科, 特任助教 (30516290)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 骨芽細胞 / 脂肪細胞 / 間葉系細胞 / 転写因子 / c-Maf / 骨粗鬆症 / 脂肪髄 / 老化

Research Abstract

Mesenchymal stem cells have a multipotent differentiation capacity into osteoblasts and adipocytes. Aging tips this balance in favor of the latter, thus inducing bone loss accompanied by fatty marrow, but the mechanism remains elusive. Here we show that Maf play an important role in bone aging.

Research Products

• [Journal Article] Efficient Transient rescue of hematopoietic mutant phenotypes in zebrafish using Tol2-mediated transgenesis (2010)
  • Author(s): Takeuchi M, Kaneko H, Nishikawa K, Kawakami K, Yamamoto M, Kobayashi M
  • Journal Title: Development growth and differentiation 52 Pages: 245-50
  • NAID: 10027563994
• [Journal Article] Blimp1-mediated repression of negative regulators is required for osteoclast differentiation (2010)
  • Author(s): Nishikawa K, Nakashima T, Hayashi M, Fukunaga T, Kato S, Kodama T, Takahashi S, Calame K, Takayanagi H
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America 107 Pages: 3117-22
• [Journal Article] Blimpl-mediated repression of negative regulators is required for osteoclast differentiation (2010)
  • Author(s): Keizo Nishikawa
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America 107 Pages: 3117-22
  • Peer Reviewed
• [Journal Article] Efficient Transient rescue of hematopoietic mutant phenotypes in zebra fish using To12-mediated transgenesis (2010)
  • Author(s): Miki Takeuchi
  • Journal Title: Development Growth and Differentiation 52 Pages: 245-50
  • Peer Reviewed
• [Presentation] 加齢に伴う骨量減少を制御する転写メカニズムの探索 (2009)
  • Author(s): 西川恵三
  • Organizer: 第3回Bone Research Seminar(中外製薬株式会社)
  • Place of Presentation: 東京
  • Year and Date: 2009-02-27
• [Presentation] 骨髄間葉系細胞の運命決定機構と老化 (2009)
  • Author(s): 西川恵三
  • Organizer: 第6回 Osteoimmunology forum (武田薬品工業株式会社・ワイス株式会社共催)
  • Place of Presentation: 東京
  • Year and Date: 2009-02-21
• [Presentation] 骨髄間葉系細胞の運命決定機構と老化 (2009)
  • Author(s): 西川恵三
  • Organizer: 第6回Osteoimunology forum(武田薬品工業株式会社・ワイス株式会社共催)
  • Place of Presentation: 東京
  • Year and Date: 2009-02-21
• [Presentation] 骨芽細胞分化を司る転写制御機構の老化に伴う変化のメカニズム (2009)
  • Author(s): 西川恵三
  • Organizer: 第1定量生物研究会
  • Place of Presentation: 東京
• [Presentation] 加齢に伴う骨量減少を制御する転写メカニズムの探索 (2009)
  • Author(s): 西川恵三
  • Organizer: 第3回 Bone Research Seminar (中外製薬株式会社)
  • Place of Presentation: 東京
• [Presentation] 加齢に伴い発現変動する転写因子Mafの細胞分化に及ぼす影響 (2008)
  • Author(s): 西川 恵三, 高橋智, 高柳広
  • Organizer: 第31回日本分子生物学会年会 第81回目本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] 加齢に伴う骨量減少の原因となる転写メカニズムの探索 (2008)
  • Author(s): 西川 恵三, 竹田秀, 山口朗, 高柳広
  • Organizer: 第26回目木骨代謝学会学術集
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-29
• [Presentation] 加齢に伴う骨量減少の原因となる転写メカニズムの探索 (2008)
  • Author(s): 西川恵三, 竹田秀, 山口朗, 高柳広
  • Organizer: 第26回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 加齢に伴い発現変動する転写因子Mafの細胞分化に及ぼす影響 (2008)
  • Author(s): 西川恵三, 高橋智, 高柳広
  • Organizer: 第31回日本分子生物学会年会 第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸