An immunohistochemical study of the similarity between the synovial lining cells in the temporomandibular joint and osteoclasts.

• Project/Area Number: 20890074
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Morphological basic dentistry
• Research Institution: Niigata University
• Principal Investigator: SUZUKI Akiko Niigata University, 医歯学系, 特任助教 (70509538)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 顎関節 / 滑膜表層細胞 / 破骨細胞 / イオンチャネル / カベオラ / カルシウムイオンチャネ

Research Abstract

顎関節における炎症性疾患の病態の主体となる滑膜表層細胞と破骨細胞にはcaveolin-3が発現する。両細胞に共通したイオンチャネルや受容体の存在を検索することを目的として、成獣ラット顎関節において特異抗体を用いた免疫組織学的検索を行った。破骨細胞ではT型、L型、N型電位依存性カルシウムイオンチャネルやENaCが、滑膜表層細ではT型チャネルやENaCが発現しており、これらはカルシウムシグナリングやイオン濃度変化に対する恒常性の維持に関与することが示唆された。

Research Products

• [Journal Article] Immunohistochemical detection of ENaC beta in the terminal Schwann cells associtated with the periodontal Ruffini endings of the rat incidor (2009)
  • Author(s): Hitomi Y, Suzuki A, Kawano Y, Nozawa-Inoue K, Inoue M, Maeda T
  • Journal Title: Biomed Res 30(2) Pages: 113-119
  • Peer Reviewed
• [Journal Article] Differential cell-specific localization of Cav-1 and Ca2+-ATPase in termial Schwann cells and mechanoreceptive Ruffini endings in the periodontal ligament of the rat incisor (2009)
  • Author(s): Iizuka N*, Suzuki A*, Nozawa-Inoue K, Kawano Y, Nandasena BGTL, Okiji T, Maeda T
  • Journal Title: J. Anat 214(2) Pages: 267-274
  • Peer Reviewed
• [Journal Article] mmunohistochemical detection of nestin in the periodontal Ruffini endings of the rat incisor (2009)
  • Author(s): Saito S*, Suzuki A*, nozawa-Inoue K, Kawano Y, Hoshino M, Saito C, Maeda T
  • Journal Title: Neurosci. Lett 449 Pages: 195-200
  • Peer Reviewed
• [Journal Article] Immunohistochemical detection of ENaCbeta in the terminal Schwann cells associated with the periodontal Ruffini endings of the rat incisor. (2009)
  • Author(s): Akiko Suzuki, (Equally contribution)
  • Journal Title: Biomedical Research 30(2) Pages: 113-119
  • Peer Reviewed
• [Journal Article] Differential cell-specific location of Cav-1 and Ca2+ATPase in terminal Schwann cells and mechanoreceptive Ruffini endings in the periodontal ligament of the ratincisor. (2009)
  • Author(s): Akiko Suzuki(contribution as the first author)
  • Journal Title: J Anatomy 214(2) Pages: 267-274
  • Peer Reviewed
• [Journal Article] Immunohistochemical detection of nestin in the periodontal Ruffini endings of the rat incisor. (2009)
  • Author(s): Akiko Suzuki(contribution as the first author)
  • Journal Title: Neurosci. Lett. 449(3) Pages: 195-200
  • Peer Reviewed
• [Presentation] 顎関節関節円板の発達におけるネスチンとGFAPの局在変化 (2009)
  • Author(s): 鈴木晶子
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岩手県
• [Presentation] ラット顎関節滑膜の発達におけるネスチンの発現 (2009)
  • Author(s): 鈴木晶子
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山県