Combination therapy of hypothermia and thrombolysis in acute ischemic stroke
| Project/Area Number |
20890103
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Mie University |
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Principal Investigator |
YATA Kenichiro Mie University, 大学院・医学系研究科, 産学官連携研究員 (40467361)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥2,106,000 (Direct Cost: ¥1,620,000、Indirect Cost: ¥486,000)
Fiscal Year 2009: ¥936,000 (Direct Cost: ¥720,000、Indirect Cost: ¥216,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 血栓溶解療法 / 血液・脳関門 / 内皮細胞 / t-PA / 低体温療法 / 血液脳関門 / 微小循環障害 / 白血球rolling / 白血球adhesion / 二光子レーザー顕微鏡 / 脳浮腫 / 血管内皮細胞 |
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| Research Abstract |
Thrombolysis therapy is essentially limited by the short therapeutic window and its potential side effects. The present study investigates whether thrombolysis alone or in combination with hypothermia has beneficial effects after experimental acute ischemic stroke. Hypothermia reduces leukocyte rolling and adhesion, and protects the blood brain barrier.
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Report
(3 results)
Research Products
(4 results)
