Does the liver transplant from fatty liver become possible?- Ischemia reperfusion injury and liver transplantation model in rat.

• Project/Area Number: 20890105
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Mie University
• Principal Investigator: KISHIWADA Masashi Mie University, 医学部附属病院, 助教 (40501961)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000); Fiscal Year 2009: ¥1,248,000 (Direct Cost: ¥960,000、Indirect Cost: ¥288,000); Fiscal Year 2008: ¥1,404,000 (Direct Cost: ¥1,080,000、Indirect Cost: ¥324,000)
• Keywords: 虚血再灌流障害 / トロンボモジュリン / 肝細胞 / 類洞内皮細胞 / Kuppfer細胞 / 凝固・抗凝固因子 / 炎症性サイトカイン / 脂肪肝 / 炎症反応 / 虚血再還流障害 / 類洞内皮障害 / TM / ラット / 肝移植 / 細胞単離 / 微小循環障害

Research Abstract

rhsTM is useful for prevention of the HEPs and SECs damage and KCs activation induced by ischemia reperfusion injury. Our present study also suggests that disturbance of hepatic microcirculation is induced in part by intrasinusoidal microthrombus formation and by locally released inflammatory cytokines from KCs.

Research Products

• [Journal Article] The cytoprotective effects of addition of activated protein C into preservation solution on small-for-size grafts in rats. (2010)
  • Author(s): Kuriyama N, Isaji S, Hamada T, Kishiwada M, Ohsawa I, Usui M, Sakurai H, Tabata M, Hayashi T, Suzuki K.
  • Journal Title: Liver Transpl 16(1) Pages: 1-11
  • Peer Reviewed
• [Journal Article] Regulatory mechanisms of C4b-binding protein (C4BP)alpha and beta expression in rat hepatocytes by lipopolysaccharide and interleukin-6. (2008)
  • Author(s): Kishiwada M, Hayashi T, Yuasa H, Fujii K, Nishioka J, Akita N, Tanaka H, Ido M, Okamoto T, Gabazza EC, Isaji S, Suzuki K.
  • Journal Title: J Thromb Haemost 6(11) Pages: 1858-67
  • Peer Reviewed
• [Presentation] The Effect of Thrombomodulin on liver cells in Hepatic Ischemia Reperfusion Injury (2009)
  • Author(s): 岸和田昌之
  • Organizer: American transprant congress 2009
  • Place of Presentation: ボストン (アメリカ)
  • Year and Date: 2009-06-01
• [Presentation] The Effect of Thrombomodulin on liver cells in Hepatic Ischemia Reperfusion Injury (2009)
  • Author(s): Kishiwada M, Kuriyama N, Hamada T, Mizuno S, Usui M, Sakurai S, Tabata M, Hayashi T, Suzuki K, Isaji S
  • Organizer: 学会名: American transplant Congress 2009
  • Place of Presentation: Bostin, MA, USA
• [Presentation] 肝虚血再還流障害モデルラットに対する組換えヒト可溶性トロンボモジュリンの保護効果 (2009)
  • Author(s): 岸和田昌之, 林辰弥, 安積良紀, 栗山直久, 濱田賢司, 水野修吾, 臼井正信, 桜井洋至, 田端正巳, 伊佐地秀司, 鈴木宏治
  • Organizer: 第109回日本外科学会
  • Place of Presentation: 福岡
• [Presentation] Thrombomodulin Protects Against Hepatic Ischemia Reperfusion Injury in the Rat (2008)
  • Author(s): 岸和田昌之
  • Organizer: American Transplant Congress 2008
  • Place of Presentation: トロント(カナダ)
  • Year and Date: 2008-06-02
• [Presentation] Thrombomodulin Protects Against Hepatic Ischemia Reperfusion Injury in the Rat (2008)
  • Author(s): Kishiwada M, Isaji S, Kuriyama N, Ohsawa I, Hamada T, Usui M, Sakurai H, Tabata M, Hayashi T, Esteban C. Gabazza, Suzuki K
  • Organizer: American transplant Congress 2008
  • Place of Presentation: Tront、Canada