The association between TSP1 polymorphism and treatment efficacy of heart failure

• Project/Area Number: 20890115
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Applied pharmacology
• Research Institution: Osaka University
• Principal Investigator: NONEN Shinpei Osaka University, 薬学部, 講師 (40467527)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 心不全 / β遮断薬 / TSP1 / 遺伝子多型

Research Abstract

I investigate the association between inter-individual variability of ss-blocker responsiveness in heart failure and TSP1 Thr523Ala polymorphism. I also perform in vitro functional analysis of TSP1 Thr523Ala. TSP1 Thr523Ala was associated with response to β-blockers in heart failure. Ala-523 TSP1 construct was lower in protein expression and translation efficacy than Thr-523 TSP1 construct.

Research Products

• [Presentation] 心不全治療におけるβ遮断薬反応性の個人差とThrombospondin 1遺伝子多型との関連 (2008)
  • Author(s): 南畝晋平, 上野由香子, 岡本洋, 藤尾慈, 竹本恭彦, 葭山稔, 寺崎文生, 大塚薫, 岩尾洋, 東純一
  • Organizer: 第2回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 京都大学薬学部記念講堂
  • Year and Date: 2008-12-21
• [Presentation] 心不全治療におけるβ遮断薬反応性の個人差とThrombospondin1遺伝子多型との関連 (2008)
  • Author(s): 南畝晋平, 上野由香子, 岡本洋, 藤尾慈, 竹本恭彦, 葭山稔, 寺崎文生, 大塚薫, 岩尾洋, 東純
  • Organizer: 第2回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 京都大学薬学部記念講堂
  • Year and Date: 2008-12-21
• [Presentation] 心不全治療におけるβ遮断薬反応性の個人差とThrombospondin 1遺伝子多型との関連 (2008)
  • Author(s): 上野由香子, 南畝晋平, 岡本洋, 藤尾慈, 竹本恭彦, 葭山稔, 寺崎文生, 大塚薫, 岩尾洋, 東純一
  • Organizer: 第29回日本臨床薬理学会年会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2008-12-06
• [Presentation] 心不全治療におけるβ遮断薬反応性の個人差とThrombospondin1遺伝子多型との関連 (2008)
  • Author(s): 上野由香子, 南畝晋平, 岡本洋, 藤尾慈, 竹本恭彦, 葭山稔, 寺崎文生, 大塚薫, 岩尾洋, 東純
  • Organizer: 第29回日本臨床薬理学会年会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2008-12-06