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The role of Interleukin-6 family cytokines in repair and tumorigenesis in the lung.

Research Project

Project/Area Number 20890116
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionOsaka University

Principal Investigator

KIDA Hiroshi  Osaka University, 医学部附属病院, 特任助教(常勤) (80512988)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Mitsuhiro  大阪大学, 大学院・医学系研究科, 助教 (90359844)
Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
Keywords幹細胞 / 肺癌 / Stat3 / ウレタン / ナフタレン / ノックアウトマウス / 気道上皮幹細胞 / 肺腫瘍 / 気道上皮修復 / インターロイキン-6 / gp130 / STAT3 / 肺特異的ノックアウトマウス
Research Abstract

Urethane-induced tumorigenesis was suppressed in the lungs of airway epithelium-specific knockout mice of Stat3 (Stat3^<Δ/Δ>) compared to control mice, suggesting that Stat3 in airway epithelium was required for the tumor growth in the lung. Immunohistochemistry did not show any significant differences in differentiation, proliferation or angiogenesis in the tumor. However, bronchoalveolar lavage (BAL) revealed that the local inflammation was significantly increased in the lung of Stat3^<Δ/Δ> compared to control mice, suggesting the possibility that tumor suppression was mediated by the increased inflammation in the lung of Stat3^<Δ/Δ>.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (5 results)

All 2009 2008 Other

All Journal Article (2 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] 気道上皮修復におけるGP130-STAT3シグナルの役割2009

    • Author(s)
      木田博, 吉田光宏, 池上眞知子, Jeffrey A. Whitsett
    • Journal Title

      分子呼吸器病学 Vbl.13

      Pages: 125-128

    • Related Report
      2009 Final Research Report
  • [Journal Article] 気道上皮修復におけるGP130-STAT3シグナルの役割2009

    • Author(s)
      木田博, 吉田光宏, 池上眞知子, Jeffrey A. Whitsett
    • Journal Title

      分子呼吸器病学 13

      Pages: 125-128

    • Related Report
      2008 Annual Research Report
  • [Presentation] 気道上皮修復におけるGP130-STAT3シグナルの役割2008

    • Author(s)
      木田博, 吉田光宏, 川瀬一郎, Jeffrey A. Whitsett
    • Organizer
      肺サーファクタント分子病態研究会
    • Place of Presentation
      札幌
    • Year and Date
      2008-07-05
    • Related Report
      2009 Final Research Report
  • [Presentation] Gp130-Stat3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium.2008

    • Author(s)
      Kida H, Mucenski ML, Thitoff AR, LeCras TD, Ikegami M, Mifiler W, Whitsett JA
    • Organizer
      American Thoracic Society
    • Place of Presentation
      トロント
    • Year and Date
      2008-05-18
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/imed3/lab_8/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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