Research Project
Grant-in-Aid for Young Scientists (Start-up)
The uterine endometrium undergoes dramatic structural and functional changes to allow the embryo to attach and implant in early pregnancy. In mice, macrophages are recruited into the endometrium by exposure to seminal plasma and these cells appear able to influence local cell communication and tissue remodeling events to promote uterine receptivity for embryo implantation. Our previous study showed that U937 macrophages regulate embryo adhesion molecule expression in human endometrial cells via LIF-mediated STAT3 signalling. In this study, we utilized an in vitro model comprising peripheral blood monocytes (PBMC) and Ishikawa cells to further explore regulation of macrophage-uterine epithelial cell communication. The signaling characteristics of PBMCs are changed by exposure to ovarian steroid hormones in the menstrual cycle, as well as by male seminal plasma, and that these factors influence PBMC capacity to regulate uterine epithelial cell adhesion molecule expression.
All 2010 2009 2008 Other
All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (22 results) Remarks (1 results)
Am J Reprod Immunol 63(2)
Pages: 137-143
Indian J Physiol Pharmacol. 54(5)
Pages: 27-32
医学のあゆみ 233(2)
Pages: 141-145
医学のあゆみ 233巻(2)
Am J Reprod Immunol 62(1)
Pages: 44-50
生殖内分泌学会雑誌 14
Pages: 35-40
Am J Reprod Immunol. 62(1)
産婦人科の実際 57(2)
Pages: 217-226
