Analysis of mechanisms of substances which inhibit Porphyromonas gingivalis biofilm formation

• Project/Area Number: 20890121
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Conservative dentistry
• Research Institution: Osaka University
• Principal Investigator: ASAHI Yoko Osaka University, 歯学部附属病院, 医員 (50456943)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,172,000 (Direct Cost: ¥2,440,000、Indirect Cost: ¥732,000); Fiscal Year 2009: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000); Fiscal Year 2008: ¥1,664,000 (Direct Cost: ¥1,280,000、Indirect Cost: ¥384,000)
• Keywords: ポルフィロモナスジンジバリス / バイオフィルム / クオラムセンシング / 阻害薬オートインデューサー / modified Robbins device / 阻害薬 / オートインデューサー

Research Abstract

Inhibitory mechanisms of autoinducer (AI) analogues on Porphyromonas gingivalis, a major periodontal pathogen, were investigated. By chronological observation, AI analogues affected on P.gingivalis biofilm growth. There were no effects on initial attachment and matured biofilm.

Research Products

• [Journal Article] Effects of N-acyl homoserine lactone analogs on Porphyromonas gingivalis biofilm formation (2010)
  • Author(s): Yoko Asahi, Yuichiro Noiri, Jun Igarashi, Hiroaki Asai, Hiroaki Suga, Shigeyuki Ebisu.
  • Journal Title: Journal of Periodontal Research Vol.45 Pages: 255-261
  • Peer Reviewed
• [Journal Article] Effects of N-acyl homoserine lactone analogues on Porphyrom onas gingivalis biofilm formation. (2010)
  • Author(s): Asahi Y., et al.
  • Journal Title: Journal of Periodontal Research 45 Pages: 225-261
  • Peer Reviewed
• [Journal Article] Quorum sensingシグナル物質の類似化合物がPorphyromonas gingivalisのバイオフィルム形成に及ぼす影響の検索 (2009)
  • Author(s): 朝日陽子, 野杁由一郎, 恵比須繁之, 五十嵐潤, 朝井洋明, 菅裕明
  • Journal Title: Bacterial Adherence& Biofilm Vol.22 Pages: 109-114
• [Journal Article] Quorum sensingシグナル物質の類似化合物がPorphyromonas gingivalisのバイオフィルム形成に及ぼす影響の検索 (2009)
  • Author(s): 朝日陽子, ら
  • Journal Title: Bacterial Adherence & Biofilm 22 Pages: 109-114
• [Journal Article] Quorum sensingシグナル物質の類似化合物がPorphyro摺onasgingivalisのバイオフィルム形成に及ぼす影響の検索 (2009)
  • Author(s): 朝日陽子ら
  • Journal Title: Bacterial Adherence & Biofilm 22(印刷中)
• [Presentation] クオラムセンシング関連物質と抗菌剤の併用がPorphyromonas gingivalisのバイオフィルム形成に及ぼす影響 (2009)
  • Author(s): 朝日陽子, ら
  • Organizer: 第131回日本歯科保存学会
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2009-10-29
• [Presentation] クオラムセンシング関連物質と抗菌剤の併川がPorphyromonas gingivalisのバイオフィルム形成に及ぼす影響 (2009)
  • Author(s): 朝日陽子, ら
  • Organizer: 日本歯科保存学会(131回)
  • Place of Presentation: 仙台市
  • Year and Date: 2009-10-29
• [Presentation] Homoserine lactone analogs inhibited Porphyromonas gingivalis biofilm growth (2009)
  • Author(s): Asahi Y., et al
  • Organizer: 87th General Session & Exhibition of the IADR
  • Place of Presentation: Miami, USA.
  • Year and Date: 2009-04-03
• [Presentation] Quorum sensingシグナル物質の類似化合物がPorphyromonas gingivalisのバイオフィルム形成に及ぼす影響の検索 (2008)
  • Author(s): 朝日陽子, ら
  • Organizer: Bacterial Adherence & Biofilm第22回学術集会
  • Place of Presentation: 兵庫県立淡路夢舞台国際会議場(兵庫県).
  • Year and Date: 2008-07-05
• [Presentation] クオラムセンシング関連物質がPorphyromonas gingivalisのバイオフィルム形成に及ぼす影響の検索 (2008)
  • Author(s): 朝日陽子, ら
  • Organizer: 第128回日本歯科保存学会
  • Place of Presentation: 朱鷺メッセ(新潟県).
  • Year and Date: 2008-06-05
• [Presentation] クオラムセンシング関連物質が、Porphyromonas gingivalisのバイオフィルム形成に及ぼす影響の検索 (2008)
  • Author(s): 朝日陽子ら
  • Organizer: 第128回日本歯科保存学会春季学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2008-06-05