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Analysis of signaling pathways induced by the binding of IL-1・to integrins

Research Project

Project/Area Number 20890126
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionKobe University

Principal Investigator

SAEGUSA Jun  Kobe University, 大学院・医学研究科, 特命助教 (20514970)

Co-Investigator(Renkei-kenkyūsha) TAKADA Yoshikazu  , カリフォルニア大学デービス校, 教授
Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
Keywordsインターロイキン-1 / インテグリン / 関節リウマチ / サイトカイン / 滑膜細胞
Research Abstract

Interleukin-1・(IL-1・) is a proinflammatory cytokine driving local as well as systemic inflammation by binding to its specific receptor, IL-1R type I, on target cells. In this study, we demonstrated that IL-1・・also specifically binds to integrin, which is known as a cell adhesion molecule. In addition, we showed that the integrin-binding site of IL-1・is distinct from the IL-1R-binding site using mutagenesis. Furthermore, we found that IL-1・・can activate MAP kinase pathway or NF-・B pathway in a manner independent of binding to IL-1R.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (26 results)

All 2010 2009 2008 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (12 results) Book (2 results)

  • [Journal Article] A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist.2010

    • Author(s)
      Y amaji S, Saegusa J, Ieguchi K, Fujita M, Takada YK, Takada Y.
    • Journal Title

      PLoS One. 5(4)

      Pages: 10273-10273

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A T cell-binding fragment of fibrinogen can prevent autoimmunity.2010

    • Author(s)
      Takada Y, Ono Y, Saegusa J, Mitsiades C, Mitsiades N, Tsai J, He Y, Maningding E, Coleman A, Ramirez-Maverakis D, Rodriquez R, Takada Y, Maverakis E.
    • Journal Title

      J Autoimmun. 34(4)

      Pages: 453-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The direct binding of insulin-like growth factor-1 (IGF-1) to integrin・v・3 is involved in IGF-1 signaling.2009

    • Author(s)
      Saegusa J, Yamaji S, Ieguchi K, Wu CY, Lam KS, Liu FT, Takada YK, Takada Y.
    • Journal Title

      J Biol Chem. 284(36)

      Pages: 24106-14

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis.2009

    • Author(s)
      Saegusa J, Hsu DK, Chen HY, Yu L, Fermin A, Fung MA, Liu FT.
    • Journal Title

      Am J Pathol. 174(3)

      Pages: 922-31

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The direct binding of insulin-like growth factor-1(IGF-1)to integrin alphavbeta3 is involved in IGF-1 signaling2009

    • Author(s)
      Saegusa J
    • Journal Title

      J Biol Chem. 284

      Pages: 24106-14

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis.2009

    • Author(s)
      Saegusa J
    • Journal Title

      Am J Pathol. 174

      Pages: 922-31

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins・v・3 and・4・1 and induces proliferation of monocytic cells in an integrin-dependent manner.2008

    • Author(s)
      Saegusa J, Akakura N, Wu CY, Hoogland C, Ma Z, Lam KS, Liu FT, Takada Y K, Takada Y.
    • Journal Title

      J Biol Chem. 283(38)

      Pages: 26107-15

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation.2008

    • Author(s)
      Saegusa J, Hsu DK, Liu W, Kuwabara I, Kuwabara Y, Yu L, Liu FT.
    • Journal Title

      J Invest Dermatol. 128(10)

      Pages: 2403-11

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4betal and induces proliferation of monocytic cells in an integrin-dependent manner2008

    • Author(s)
      Saegusa J
    • Journal Title

      J Biol Chem 283

      Pages: 26107-15

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation.2008

    • Author(s)
      Saegusa J
    • Journal Title

      J Invest Dermatol 128

      Pages: 2403-11

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.2008

    • Author(s)
      Mori S
    • Journal Title

      J Biol Chem 283

      Pages: 18066-75

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A T cell-binding fragment of fibrinogen can prevent autoimmunity

    • Author(s)
      Takada Y
    • Journal Title

      J Autoimmun. (in press, 掲載確定)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] An integrin binding- defective FGFR50E mutant promotes synoviocyte apoptosis by activating caspase-9 through modulation of Bcl-2 and Bim expression.2009

    • Author(s)
      J Saegusa
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-04
    • Related Report
      2009 Final Research Report
  • [Presentation] An integrin binding-defective FGF^<R50E> mutant promotes synoviocyte apoptosis by activating caspase-9 through modulation of Bcl-2 and Bim expression2009

    • Author(s)
      三枝淳
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Secretory Phospholipase A2 Group IIA Binds to Integrin avβ3 and Induces Proinflammatory Signaling.2009

    • Author(s)
      J Saegusa
    • Organizer
      第75回米国リウマチ学会
    • Place of Presentation
      フィラデルフィア
    • Year and Date
      2009-10-20
    • Related Report
      2009 Final Research Report
  • [Presentation] Secretory Phospholipase A2 Group IIA Binds to Integrin avss3 and Induces Proinflammatory Signaling2009

    • Author(s)
      三枝淳
    • Organizer
      American College of Rheumatology, Annual Scientific Meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 急性期蛋白ホスホリパーゼA2 group IIAはインテグリンと結合して細胞内に炎症性シグナルを伝える2009

    • Author(s)
      三枝淳
    • Organizer
      第56回日本臨床検査医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2009-08-27
    • Related Report
      2009 Final Research Report
  • [Presentation] 急性期蛋白ホスホリパーゼA2 group IIAはインテグリンと結合して細胞内に炎症性シグナルを伝える2009

    • Author(s)
      三枝淳
    • Organizer
      第56回日本臨床検査医学会総会・学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2009-08-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] インテグリンはホスホリパーゼA2 group IIA(sPLA2-IIA)のレセプターとして働き炎症性シグナルを伝達する2009

    • Author(s)
      三枝淳
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-25
    • Related Report
      2009 Final Research Report
  • [Presentation] インテグリンはホスホリパーゼA2 group IIA(sPLA2-ILA)のレセプターとして働き炎症性シグナルを伝達する2009

    • Author(s)
      三枝淳
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] ガレクチン-3は皮膚アレルギー性炎症の進行に重要な役割を果たしている2008

    • Author(s)
      三枝淳
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Galectin-3 promotes activation of AKT and protects keratinocytes from apoptosis2008

    • Author(s)
      J Saegusa
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Galectin-3 promotes activation of AKT and protects keratinocytes from apoptosis2008

    • Author(s)
      Saegusa J
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      Kyoto
    • Related Report
      2008 Annual Research Report
  • [Presentation] ガレクチン-3は皮膚アレルギー性炎症の進行に重要な役割を果たしている2008

    • Author(s)
      三枝 淳
    • Organizer
      日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Book] Galectins in Regulation of Inflammation and Immunity. In: Galectins.2008

    • Author(s)
      L iu FT, Hsu DK, Yang RY, Chen HY, Saegusa J.
    • Publisher
      Oxford University Press
    • Related Report
      2009 Final Research Report
  • [Book] Galectins2008

    • Author(s)
      Liu FT
    • Total Pages
      279
    • Publisher
      Oxford University Press
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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