Significance of NF-kappa B in radioresistant mechanism
| Project/Area Number |
20890127
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
KAWABE Tetsuya Kobe University, 医学部附属病院, 助教 (40515631)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 放射線抵抗性 / NF-kappa B / 扁平上皮がん / 放射線治療 / EGFレセプター / NF-kappaB |
|---|
| Research Abstract |
Using clinical samples, we evaluated significance of NF-kappa B in radioresistant mechanisms. The NF-kappa B showed stronger predictive ability compared to either Bcl-2 or EGF receptor. The detectability of NF-kappa B was well correlated with local tumor control. In the recurrent laryngeal cancer, the NF-kappa B expressed in the majority of cases.
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Report
(3 results)
Research Products
(50 results)
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[Journal Article] Nuclear Factor-kappaB Expression As A Novel Marker Of Radioresistance in Early-stage Laryngeal Cancer2010
Author(s)
K enji Yoshida, Ryohei Sasaki, Hideki Nishimura, Yoshiaki Okamoto, Yoko Suzuki, Tetsuya Kawabe, Miki Sito, Naoki Otsuki, Yoshitake Hayashi, Toshinori Soejima, Kenichi Nibu, Kazuro Sugimura.
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Journal Title
HEAD&NECK 32(5)
Pages: 646-55
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[Presentation] 聴器扁平上皮癌に対する治療経験2009
Author(s)
吉田賢史, 中林美日, 佐々木良平, 岡本欣晃, 西村英輝, 河邊哲也, 長谷川信吾, 斉藤幹, 大月直樹, 丹生健一, 杉村和朗
Organizer
第33回日本頭頚部癌学会
Place of Presentation
札幌
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[Presentation] 頭頚部癌に対する集学的治療の取り組み中での放射線生物学の役割2009
Author(s)
佐々木良平, 西村英輝, 吉田賢史, 河邊哲也, 宮脇大輔, 杉村和朗, 清田尚臣, 奥野達哉, 南川勉, 斉藤幹, 大月直樹, 丹生健一
Organizer
第48回日本医学放射線学会生物部会学術大会
Place of Presentation
富山
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[Presentation] 当院における中枢神経原発悪性リンパ腫(PCNSL)の放射線治療経験2009
Author(s)
石原武明, 吉田賢史, 佐々木良平, 西村英輝, 河邊哲也, 宮脇大輔, 上薗玄, 上原和之, 中山雅央, 杉村和朗*, 篠山隆, 甲村英二
Organizer
第293回日本医学放射線学会関西地方会
Place of Presentation
大阪
Related Report
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[Presentation] 聴器扁平上皮癌に対する治療経験2009
Author(s)
吉田賢史, 中林美日, 佐々木良平, 西村英輝, 河邊哲也, 岡本欣晃, 宮脇大輔, 上園玄, 石原武明, 長谷川信吾, 大月直樹, 丹生健一, 杉村和朗
Organizer
第47回日本癌治療学会学術大会
Place of Presentation
横浜
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