| Project/Area Number |
20890129
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
KAGAWA Natsuko Nara Institute of Science and Technology, 大学院・薬学研究院, 助教 (60467686)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | インドール / インドレニン / 互変異性体 / 立体選択性 / パラジウム / マグネシウム / ヨヒンビン / レゼルピン / 有機化学 / 複素環 / アリル化反応 / アルカロイド / 不斉炭素 / アリル化 / 国際情報交流 / アメリカ:スペイン |
|---|
| Research Abstract |
Medicinal components in reserpine (hypotensive drugs & tranquilizers) and ajmaline (antiarrhythmic drugs) have a common chemical structure "indole", however possess different biological activities. An indole core in the reserpine was changed into an indolenine core by organic synthetic chemistry in order to clear a chemical role of indole. The molecular structure of indolenine was identified and characterized with scientific evidence.
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