Elucidation of angiogenic factor dynamics in the structural control of regenerated bone and identification of new related genes

• Project/Area Number: 20890137
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Okayama University
• Principal Investigator: MORITANI Norifumi Okayama University, 岡山大学病院, 医員 (60467751)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: VEGF / CCN2 / CTGF / 血管新生因子 / 結合組織成長因子 / マイクロアレイ / dexamethasone / HCS-2 / 8 / 軟骨 / 転写因子 / インプラント / 骨再生 / ラット

Research Abstract

During the phase when bone is most actively regenerating, the angiogenic factors-VEGF and CCN2/CTGF proteins-are localized in osteoblasts, vascular endothelial cells, and osteoclasts near the regenerated bone. These proteins have been suggested to control bone formation and resorption and to synergistically promote bone regeneration. One hundred seventy-one candidate genes were extracted whose expression changes were related to the CCN2/CTGF gene.

Research Products

• [Journal Article] Atypical lipomatous tumor of the tongue : Report of a case. (2010)
  • Author(s): Norifumi Moritani
  • Journal Title: Acta Medica Okayama (in press)
  • Peer Reviewed
• [Journal Article] Clinical evaluation of dental implant reconstruction of grafted alveolar clefts in cleft lip and palate patients. (2009)
  • Author(s): Norifumi Moritani
  • Journal Title: Transaction of 11th International Congress on Cleft Palate and Related Craniofacial Anomalies Pages: 117-123
• [Journal Article] Role of the low-density lipoprotein receptor-related protein-1 in regulation of chondrocyte differentiation. (2009)
  • Author(s): Kazumi Kawata
  • Journal Title: Journal of cellular physiology 222 Pages: 138-148
  • Peer Reviewed
• [Journal Article] Bone formation in a rat calvarial defect model after transplanting autogenous bone marrow with beta-tricalcium phosphate. (2009)
  • Author(s): N. Shirasu.
  • Journal Title: Acta Histochetnica (in press)
  • Peer Reviewed
• [Journal Article] 超高気孔率ハイドロキシアパタイトのラット頭蓋骨骨欠損部での組織学的、X線学的観察-骨形成過程の予備的研究- (2008)
  • Author(s): 植野高章, 平田あずみ, 脇本真理, 本多浩三, 白数信明, 澤木聖子, 太田晃子, 加納みわ, 森谷徳文, 松村達志, 水川展吉, 菅原利夫
  • Journal Title: 日本顎顔面インプラント学会雑誌 6(3) Pages: 205-211
• [Journal Article] 当科における歯科インプラント前処置としての骨増量術を行った症例の病診連携の検討 (2008)
  • Author(s): 植野高章, 平田あずみ, 脇本真理, 本多浩三, 白数信明, 澤木聖子, 太田晃子, 加納みわ, 森谷徳文, 松村達志, 水川展吉, 菅原利夫
  • Journal Title: 日本顎顔面インプラント学会雑誌 6(3) Pages: 219-222
• [Journal Article] 超高気孔率ハイドロキシアパタイトのラット頭蓋骨骨欠損部での組織学的, X線学的観察-骨形成過程の予備的研究-. (2008)
  • Author(s): 植野高章
  • Journal Title: 日本顎顔面インプラント学会雑誌 6 Pages: 205-211
  • Peer Reviewed
• [Presentation] Clinical and histological study in alveolar bone following post-extraction socket augmentation using Master Graft○R granules. (2010)
  • Author(s): M. Wakimoto, T. Ueno, A. Hirata, T. Aghaloo, P.K. Moy, N. Shirasu, A. Ota, N. Moritani, M. Wakimoto, K. Sano, T. Yamada
  • Organizer: Academy of Osseointegration
  • Place of Presentation: Orland
• [Presentation] Clinical and histological study in alveolar bone following post-extraction socket augmentation using Master Graft granules. (2010)
  • Author(s): Mari Wakimoto
  • Organizer: Academy of Osseointegration
  • Place of Presentation: Orland
• [Presentation] 再生骨の立体構造制御における血管新生因子動態の解明と新規関連遺伝子の同定 (2008)
  • Author(s): 森谷徳文
  • Organizer: 岡山大学大学院医歯薬学総合研究科機能再生・再建科学専攻主催ミニ・シンポジウム
  • Place of Presentation: 岡山大学
  • Year and Date: 2008-12-16
• [Presentation] Heparanase contribute to palate fusion by degrading perlecan. (2008)
  • Author(s): A. Hirata.
  • Organizer: XIX Congress of the European Association for Cranio-Maxillo- Facial Surgery
  • Place of Presentation: Bologna
• [Book] Clinical evaluation of dental implant reconstruction of grafted alveolar clefts in cleft lip and palate patients (2009)
  • Author(s): N. Moritani, K. Mishima, T. Ueno, T. Yamada, Y. Ikeya, A. Ota, D. Janune, T. Matsumura, M. Wakimoto
  • Publisher: Academy of Medicine