Protection for inner ear against noise injury and aging by heat shock response

• Project/Area Number: 20890146
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Yamaguchi University
• Principal Investigator: MIKURIYA Takefumi Yamaguchi University, 医学部附属病院, 助教 (00467797)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2009: ¥1,534,000 (Direct Cost: ¥1,180,000、Indirect Cost: ¥354,000); Fiscal Year 2008: ¥1,716,000 (Direct Cost: ¥1,320,000、Indirect Cost: ¥396,000)
• Keywords: 内耳保護 / 老人性難聴 / 音響障害 / 熱ショック応答 / 老人性難徳

Research Abstract

Heat shock protein inducer protect against noise injury in guinea pig and mice. In this response, the pattern of induction of Hsp is interestingly different from other organs. Moreover this reagent prevent age related hearing loss and loss of sensory neuron. These results indicate that heat shock response in inner ear is vital response.

Research Products

• [Journal Article] 蝸牛における音響障害後の炎症性サイトカインの動向 (2010)
  • Author(s): 中本哲也、御厨剛史、菅原一真、下郡博明、山下裕司
  • Journal Title: 頭頸部自律神経 24 Pages: 15-15
  • NAID: 10030883280
  • Peer Reviewed
• [Journal Article] 蝸牛における音響障害後の炎症性サイトカインの動向 (2010)
  • Author(s): 中本哲也
  • Journal Title: 頭頸部自律神経 24 Pages: 15-15
• [Journal Article] 熱ショック応答と内耳保護機能 (2009)
  • Author(s): 山下裕司、御厨剛史
  • Journal Title: 耳鼻咽喉科展望 52
  • Peer Reviewed
• [Journal Article] 熱ショック応答と内耳保護機能 (2009)
  • Author(s): 山下裕司
  • Journal Title: 耳鼻咽喉科展望 52 Pages: 10-16
• [Journal Article] 熱ショック応答誘導剤による内耳熱ショック応答の修飾と音響ストレスとの関係 (2008)
  • Author(s): 御厨剛史、菅原一真、広瀬敬信、下郡博明、山下裕司
  • Journal Title: 頭頸部自律神経 22 Pages: 43-45
  • Peer Reviewed
• [Journal Article] Effect of water-soluble coenzyme Q10 on noise-induced hearing loss in guinea pigs (2008)
  • Author(s): Yoshinobu Hirose, Kazuma Sugahara, Takefumi Mikuriya, Makoto Hashimoto, Hiroaki Shimogori, Hiroshi Yamashita
  • Journal Title: Acta Oto-Laryngologica 128 Pages: 1071-1076
  • Peer Reviewed
• [Journal Article] The Free Radical Scavenger Edaravone Protects Hair Cells aganist Aminoglycoside Toxicity. (2008)
  • Author(s): Tsuguyuki Arai, Kazuma Sugahara, Takefumi Mikuriya, Yuji Miyauchi, Yoshinobu Hirose, Makoto Hashimoto, Hiroaki Shimogori, Hiroshi Yamashita
  • Journal Title: THE BULLETIN OF THE YAMAGUCHI MEDICAL SCHOOL 55 Pages: 15-20
  • Peer Reviewed
• [Journal Article] 熱ショック応答誘導剤による内耳熱ショック応答の修飾と音響ストレスの関係 (2008)
  • Author(s): 御厨剛史, 他
  • Journal Title: 頭頸部自律神経 22 Pages: 43-45
• [Journal Article] The Free Radical Scavenger Edaravone Protects Hair Cells against Aminoglycoside Toxicity (2008)
  • Author(s): Tsuguyuki Arai, 他
  • Journal Title: THE BULLETIN OF THE YAMAGUCHI MEDICAL SCHOOL 55 Pages: 15-20
  • Peer Reviewed
• [Journal Article] Effect of water-soluble coenzyme Q10 on noise-induced hearing loss in guinea pigs (2008)
  • Author(s): Yoshinobu Hirose, 他
  • Journal Title: Acta Oto-Laryngologica 128 Pages: 1071-1076
  • Peer Reviewed
• [Presentation] 加齢による内耳熱ショック蛋白質の変化について (2009)
  • Author(s): 御厨剛史
  • Organizer: 第54回日本聴覚医学会総会・学術講演会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2009-10-22
• [Presentation] マウス音響障害モデルの熱ショック応答の評価と系統間による誘導の違いの検討 (2008)
  • Author(s): 御厨剛史
  • Organizer: 第18回学術講演会・耳科学会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2008-10-16
• [Presentation] マウス音響障害モデルの熱ショック応答の評価と系統間による誘導の違いの検討 (2008)
  • Author(s): 御厨剛史, 他
  • Organizer: 第18回学術講演会・耳科学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-10-16