Strucutre and function of Sp6
| Project/Area Number |
20890151
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
HAGITA Hiroko The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 技術員 (30512123)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | Sp6 / SUMO化 / 翻訳後修飾 / メチル化 / 歯胚特異的 |
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| Research Abstract |
Sp6 is a transcription factor that is specifically expressed in the tooth germ. It is reported that Sp6 deficiency causes supernumerary teeth and the abnormality in amelogenesis. However, the molecule mechanism remains unclear. The results of the present study demonstrating that. the post-translational modification influences the Sp6 activity may become the basic knowledge for the clinical application of the tooth regeneration therapy.
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Report
(3 results)
Research Products
(1 results)
