Strucutre and function of Sp6

Research Project

Project/Area Number	20890151
Research Category	Grant-in-Aid for Young Scientists (Start-up)
Allocation Type	Single-year Grants
Research Field	Functional basic dentistry
Research Institution	The University of Tokushima
Principal Investigator	HAGITA Hiroko The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 技術員 (30512123)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
Keywords	Sp6 / SUMO化 / 翻訳後修飾 / メチル化 / 歯胚特異的
Research Abstract	Sp6 is a transcription factor that is specifically expressed in the tooth germ. It is reported that Sp6 deficiency causes supernumerary teeth and the abnormality in amelogenesis. However, the molecule mechanism remains unclear. The results of the present study demonstrating that. the post-translational modification influences the Sp6 activity may become the basic knowledge for the clinical application of the tooth regeneration therapy.

Report

(3 results)