| Project/Area Number |
20890158
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pediatric surgery
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
SAEKI Isamu Kyushu University, 大学病院, 医員 (80452762)
|
|---|
| Research Collaborator |
HAYASHIDA Makoto 九州大学, 大学病院・小児外科, 助教 (70452761)
MATSURA Toshiharu 九州大学, 大学病院・小児外科, 助教 (10532856)
TAGUCHI Tomoaki 九州大学, 大学病院・小児外科, 教授 (20197247)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
|
|---|
| Keywords | 移植・再生医療 / 小児外科 / 小腸移植 / 虚血再潅流障害 / Ischemic preconditioning / 虚血再還流障害 / 虚血再潅流障 |
|---|
| Research Abstract |
Male Lewis rats weighting 200-300g were used for this study. Rats were allocated into three groups : control (C) ; ischemic preconditioning (IPC) ; or remote ischemic preconditioning (RIPC), followed by ectopic small bowel transplantation. The values of tissue injury were significantly lower in IPC and RIPC groups than in C group at 3 hours after transplantation. Both IPC and RIPC can equally ameliorate ischemia-reperfusion injury after rat intestinal transplantation in early phase.
|
