| Project/Area Number |
20890161
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
SANUI Terukazu Kyushu University, 歯学研究院, 助教 (70507780)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 歯周組織再生 / Sprouty2 / 骨芽細胞 / 上皮細胞 / bFGF / EGF / Sprouty / FGF / ERK |
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| Research Abstract |
Sprouty was identified as an inhibitor of fibroblast growth factor (FGF) receptor in Drosophila. In mammals, four Sproutys have been identified, and specifically Sprouty2 functions as a negative regulator of receptor tyrosine kinases (RTKs) signaling. The purpose of this study was to investigate whether Sprouty2 could be new therapeutic targets for periodontal tissue regeneration. Suppression of Sprouty2 induced cell proliferation and bone mineralization of osteoblastic cells, while it diminished cell proliferation of gingival epithelial cells. In other words, inhibition of Sprouty2 may effectively allow alveolar bone to grow, with blocking the ingrowth of gingival epithelial cells toward bony defects, as well as an effect of guided tissue regeneration (GTR) methods.
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