Design and Evaluation of Novel Tumor Cell-selective Anti-cancer Drugs Using Dimethyl-α-cyclodextrin

• Project/Area Number: 20890166
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Physical pharmacy
• Research Institution: Kumamoto University
• Principal Investigator: MOTOYAMA Keiichi Kumamoto University, 大学院・生命科学研究部, 講師 (50515608)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥1,716,000 (Direct Cost: ¥1,320,000、Indirect Cost: ¥396,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥936,000 (Direct Cost: ¥720,000、Indirect Cost: ¥216,000)
• Keywords: 癌 / 薬学 / シクロデキストリン / DDS

Research Abstract

In the present study, we prepared folate (FA)-appended methylated cyclodextrin (M-CyD) to evaluate that of cancer cell-selective cytotoxicity, because FA specifically binds to folate receptor (FR), which expresses in many cancer cells. FA-appended M-CyD entered into folate receptor (FR) over-expressing cancer cells and showed significant cytotoxicity. These results suggest may provide useful information when we prepare the novel anti-tumor agents using FA and M-CyD.

Research Products

• [Journal Article] Involvement of PI3K-Akt-Bad pathway in apoptosisinduced by 2, 6-di-O-methyl-8-cyclodextrin, not 2, 6-di-Omethyl-9-cyclodextrin, through cholesterol depletion from lipid rafts on plasma membranes in cells (2009)
  • Author(s): Motoyama K, Kameyama K, Onodera R, Araki N, Hirayama F, Uekama K, Arima H
  • Journal Title: Eur. J. Pharm. Sci 38 Pages: 249-261
  • Peer Reviewed
• [Journal Article] Involvement of PI3K-Akt-Bad pathway in apoptosis induced by 2,6-di-O-methyl-β-cyclodextrin, not 2,6-di-O-methyl-α-cyclodextrin, through cholesterol depletion from lipid rafts on plasma membranes in cells (2009)
  • Author(s): Keiichi Motoyama
  • Journal Title: European Journal of Pharmaceutical Sciences 38 Pages: 249-261
  • Peer Reviewed
• [Presentation] 新規葉酸修飾メチル化シクロデキストリンの調製と物性評価 (2010)
  • Author(s): 小野寺理沙子、本山敬一、有馬英俊
  • Organizer: 第130年会日本薬学会
  • Place of Presentation: 岡山コンベンションセンター(岡山県)
  • Year and Date: 2010-03-28
• [Presentation] 葉酸修飾メチル化シクロデキストリンの調製と物性評価 (2009)
  • Author(s): 小野寺理沙子、本山敬一、有馬英俊
  • Organizer: 第26回日本薬学会九州支部大会
  • Place of Presentation: 九州大学(福岡県)
  • Year and Date: 2009-12-13