Novel roles of CYLD in the molecular pathogenesis of intractable diseases
Project/Area Number |
20890167
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Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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Allocation Type | Single-year Grants |
Research Field |
Biological pharmacy
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Research Institution | Kumamoto University |
Principal Investigator |
JONO Hirofumi Kumamoto University, 大学院・生命科学研究部, 講師 (40515483)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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Keywords | CYLD / 肺線維症 / 慢性閉塞性肺疾患 / 家族性アミロイドポリニューロパチー / 脱ユピキチン化酵素 / 遺伝性疾患 / 細菌感染症 |
Research Abstract |
Tumor suppressor CYLD has been recently shown to play important roles in the pathogenesis of various intractable diseases. In the present study, we focused on the CYLD-related diseases (1. lung fibrosis, 2. chronic obstructive pulmonary disease, 3. familial amyloidotic polyneuropathy) and revealed that CYLD acted as a deubiquitinase and involved in various diseases by suppressing intracellular signaling, such as TGFβ signal and NF-κB signal to regulate the disease-related gene expression.
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Report
(2 results)
Research Products
(33 results)
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[Journal Article] Cyclodextrin, a novel therapeutic tool for suppressing amyloidogenic transthyretin misfolding in transthyretin-related amyloidosis.2011
Author(s)
Jono H, Anno T, Motoyama K, Misumi Y, Tasaki T, Oshima T, Mori Y, Mizuguchi M, Ueda M, Shono M, Obayashi K, Arima H, Ando Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Loss of functional albumin triggers acceleration of transthyretin amyloid fibril formation in familial amyloidotic polyneuropathy.2011
Author(s)
Kugimiya T, Jono H, Saito S, Maruyama M, Kadowaki D, Misumi Y, Hoshii Y, Tasaki T, Su Y, Ueda M, Obayashi K, Shono M, Otagiri M, Ando Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Amyloid neuropathy in a younger domino liver transplanted recipient.2011
Author(s)
Obayashi K, Yamashita T, Tasaki M, Ueda M, Shono M, Jono H, Ohshima T, Ohya Y, Asonuma K, Inomata Y, Ando Y.
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Journal Title
Muscle Nerve 43
Pages: 449-450
Related Report
Peer Reviewed
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[Journal Article] Hepatic Stellate Cells Accelerate the Malignant Behavior of Cholangiocarcinoma Cells.2011
Author(s)
Okabe H, Beppu T, Hayashi H, Ishiko T, Masuda T, Otao R, Horlad H, Jono H, Ueda M, Phd SS, Ando Y, Baba H.
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Journal Title
Ann Surg Oncol 18
Pages: 1175-1184
Related Report
Peer Reviewed
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[Journal Article] Trans Soluble amyloidgenic enhancing factor Circulating via exosomes.2010
Author(s)
Tasaki M, Ueda M, Ochiai S, Tanabe Y, Murata S, Su Y, Shinriki S, Jono H, Shono M, Obayashi K, Nakamura T, Yamada M, Ando Y.
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Journal Title
Biochem Biophys Res Commun 400
Pages: 559-562
Related Report
Peer Reviewed
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[Journal Article] In Vitro and In Vivo Gene Delivery Mediated by Lactosylated Dendrimer/α-Cyclodextrin Conjugates (G2) into Hepatocytes.2010
Author(s)
Arima H, Yamashita S, Mori Y, Hayashi Y, Motoyama K, Hattori K, Takeuchi T, Jono H, Ando Y, Hirayama F, Uekama K.
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Journal Title
Journal of Controlled Release 146
Pages: 106-117
Related Report
Peer Reviewed
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[Journal Article] Differential regulation of Streptococcus pneumoniae-induced human MUC5AC mucin expression through distinct MAPK pathways.2009
Author(s)
Lim JH, Kim HJ, Komatsu K, Ha U, Huang Y, Jono H, Kweon SM, Lee J, Xu X, Zhang GS, Shen H, Kai H, Zhang W, Xu H, Li JD.
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Journal Title
Am J Transl Res 8
Pages: 300-311
Related Report
Peer Reviewed
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[Journal Article] Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma.2009
Author(s)
Shinriki S, Jono H, Ota K, Ueda M, Kudo M, Ota T, Oike Y, Endo M, Ibusuki M, Hiraki A, Nakayama H, Yoshitake Y, Shinohara M, Ando Y.
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Journal Title
Clin Cancer Res 15
Pages: 5426-5434
Related Report
Peer Reviewed
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[Journal Article] SELDI-TOF mass spectrometry evaluation of variant transthyretins for diagnosis and pathogenesis of familial amyloidotic polyneuropathy.2009
Author(s)
Ueda M, Misumi Y, Mizuguchi M, Nakamura M, Yamashita T, Sekijima Y, Ota K, Shinriki S, Jono H, Ikeda S, Suhr OB, Ando Y.
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Journal Title
Clin Chem. 55
Pages: 1223-1227
Related Report
Peer Reviewed
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[Journal Article] Synergistic induction of nuclear factor-kappaB by transforming growth factor-beta and tumour necrosis factor-alpha is mediated by protein kinase A-dependent RelA acetylation.2009
Author(s)
Ishinaga H, Jono H, Lim JH, Komatsu K, Xu X, Lee J, Woo CH, Xu H, Feng XH, Chen LF, Yan C, Li JD.
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Journal Title
Biochem J. 417
Pages: 583-591
Related Report
Peer Reviewed
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[Journal Article] Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling.2008
Author(s)
Koga T, Lim JH, Jono H, Ha UH, Xu H, Ishinaga H, Morino S, Xu X, Yan C, Kai H, Li JD.
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Journal Title
J Biol Chem 283
Pages: 12546-12554
Related Report
Peer Reviewed
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[Journal Article] Midkine as a prognostic biomarker in oral squamous cell carcinoma.2008
Author(s)
Ota K, Fujimori H, Ueda M, Shiniriki S, Kudo M, Jono H, Fukuyoshi Y, Yamamoto Y, Sugiuchi H, Iwase H, Shinohara M, Ando Y.
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Journal Title
Br J Cancer 99
Pages: 655-662
Related Report
Peer Reviewed
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[Presentation] Effect of cyclodextrins on transthyretin amyloid formation.2010
Author(s)
Jono H, Anno T, Misumi Y, Mori Y, Motoyama K, Ueda M,, Horibata Y, Shono M, Obayashi K, Arima H, Ando Y.
Organizer
XII International symposium on amyloidosis
Place of Presentation
Crown Plaza Rome, Rome, Italy.
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[Presentation] Effect of Albumin on Transthyretin Amyloid Formation.2008
Author(s)
Jono H, Saito S, Kugimiya T, Maruyama T, Misumi Y, Hoshii Y, Horibata Y, Ueda M, Otagiri M, Ando Y.
Organizer
VIIth International Symposium on Familial Amyloid Polyneuropathy
Place of Presentation
King's college London, London, UK.
Year and Date
2008-09-03
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