Identification and characterization of novel muscle-derived cardio protective factors

• Project/Area Number: 20890170
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: IZUMIYA Yasuhiro Kumamoto University, 大学院・生命科学研究部, 助教 (10515414)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 骨格筋 / 心血管保護 / 分泌因子

Research Abstract

We screened to identify novel muscle-derived factors that act on cardiovascular systems. We found that fibroblast growth factor-21 (FGF-21) and follistatin-like 1 (Fstl1) are a novel myokine that confers cardiovascular protection. Increasing in skeletal muscle mass, such as resistance training exercise, could be a useful treatment for cardiovascular diseases through production of cardiovascular protective myokines.

Research Products

• [Journal Article] Effects of Fixed-Dose Isosorbide Dinitrate/Hydralazine on Diastolic Function and Exercise Capacity in Hypertension-Induced Diastolic Heart Failure (2009)
  • Author(s): Wilson RM, De Silva DS, Sato K, Izumiya Y, Sam F
  • Journal Title: Hypertension 54(3) Pages: 583-90
  • Peer Reviewed
• [Journal Article] Myogenic Akt signaling upregulates the utrophin-glycoprotein complex and promotes sarcolemma stability in muscular dystrophy (2009)
  • Author(s): Peter AK, Ko CY, Kim MH, Hsu N, Ouchi N, Rhie S, Izumiya Y, Zeng L, Walsh K, Crosbie RH
  • Journal Title: Hum Mol Genet 18(2) Pages: 318-327
  • Peer Reviewed
• [Journal Article] Effects of Fixed-Dose Isosorbide Dinitrate/Hydralazine on Diastolic Function and Exercise Capacity in Hypertension-Induced Diastolic Heart Failure (2009)
  • Author(s): Richard M.Wilson
  • Journal Title: Hypertension 54 Pages: 583-590
  • Peer Reviewed
• [Journal Article] Myogenic Akt signaling upregulates the utrophin-glycoprotein complex and promotes sarcolemma stability in muscular dystrophy (2009)
  • Author(s): Angela K.Peter
  • Journal Title: Human Molecular Genetics 18 Pages: 318-327
  • Peer Reviewed
• [Journal Article] FGF21 is an Akt-regulated myokine (2008)
  • Author(s): Izumiya Y, Bina HA, Ouchi N, Akasaki Y, Kharitonenkov A, Walsh K
  • Journal Title: FEBS Lett 582(27) Pages: 3805-3810
  • Peer Reviewed
• [Journal Article] Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric oxide synthesis-dependent mechanism (2008)
  • Author(s): Ouchi N, Oshima Y, Ohashi K, Higuchi A, Ikegami C, Izumiya Y, Walsh K
  • Journal Title: J Biol Chem 283(47) Pages: 32802-11
  • Peer Reviewed
• [Journal Article] Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart (2008)
  • Author(s): Oshima Y, Ouchi N, Sato K, Izumiya Y, Pimentel DR, Walsh K
  • Journal Title: Circulation 117 Pages: 3099-108
  • Peer Reviewed
• [Journal Article] FGF21 is an Akt-regulated myokine. (2008)
  • Author(s): Yasuhiro Izumiya
  • Journal Title: FEBS Lett. 582(27) Pages: 3805-3810
  • Peer Reviewed
• [Journal Article] Follistatin-like 1, a secreted muscle protein, promotes endothelial cellfunction and revascularization in ischemic tissue through a nitric oxidesynthesis-dependent mechanism. (2008)
  • Author(s): Noriyuki Ouchi
  • Journal Title: J Biol Chem. 283(47) Pages: 32802-32811
  • Peer Reviewed
• [Journal Article] Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secretedby the heart. (2008)
  • Author(s): Yuichi Oshima
  • Journal Title: Circulation. 117 Pages: 3099-3108
  • Peer Reviewed
• [Presentation] Coronary Plaque is Stabilized by Daily Use of Oral Nicorandil Independent of Statin-use in Patients with Stable Angina Pectoris (2010)
  • Author(s): 泉家康宏
  • Organizer: 第74回日本循環器学会総会・学術集会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2010-03-07
• [Presentation] Coronary Plaque is Stabilized by Daily Use of Oral Nicorandil Independent of Statin-use in Patients with Stable Angina Pectoris (2010)
  • Author(s): 泉家康宏
  • Organizer: 第74回 日本循環器学会総会・学術集会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2010-03-07
• [Presentation] FGF-21 is an Akt1-Regulated Skeletal Muscle-Derived Factor (2009)
  • Author(s): 泉家康宏
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-03-22
• [Presentation] FGF-21 is an Aktl-Regulated Skeletal Muscle-Derived Factor (2009)
  • Author(s): 泉家康宏
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-03-22
• [Presentation] Akt1-Mediated Skeletal Muscle Growth Leads to the Secretion of Cardiovascular Protective Cytokines (2009)
  • Author(s): 泉家康宏
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-03-21
• [Presentation] Aktl-Mediated Skeletal Muscle Growth Leads to the Secretion of Cardiovascular Protective Cytokines (2009)
  • Author(s): 泉家康宏
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-03-21
• [Book] Annual Review 2010循環器骨格筋由来液性因子による代謝制御 (2010)
  • Author(s): 泉家康宏
  • Publisher: 中外医学社
• [Book] Annual Review 2010 循環器 (2010)
  • Author(s): 泉家康宏
  • Total Pages: 8
  • Publisher: 骨格筋由来液性因子による代謝制御