Lineage tracing of EPPK1-expressing cells : toward the elucidation of the mechanisms of pancreas regeneration

• Project/Area Number: 20890172
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Kumamoto University
• Principal Investigator: MIKI Rika Kumamoto University, 発生医学研究所, COEリサーチアソシエイト (30516133)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 糖尿病 / 膵再生 / 膵β細胞 / 幹細胞

Research Abstract

The expression of Eppk1 was found in the islet cells during the regeneration process. To genetically trace the EPPK1 expressing cells in the regeneration, we have attempted to establish transgenic mouse lines and I have obtained several EPPK1-CreER transgenic mouse lines. EPPK1-CreER : Z/EG mice were injected with tamoxifen (Tm). After Tm injection, I checked GFP expression.

Research Products

• [Presentation] Lineage tracing of EPPK1-expressing cells: toward the elucidation of the mechanisms of pancreas regeneration (2009)
  • Author(s): 三木梨可、吉田哲、安川貴規、粂和彦、粂昭苑
  • Organizer: The 25th kumamoto medical bioscience symposium & G-COE Program
  • Place of Presentation: 熊本全日空ホテルニューカイ(熊本県)
• [Presentation] Lineage tracing of EPPK1-expressing cells : toward the elucidation of the mechanisms of pancreas regeneration (2009)
  • Author(s): 三木梨可
  • Organizer: The 25^<th> kumamoto medical bioscience symposium & G-COE Program
  • Place of Presentation: 熊本全日空ホテルニューカイ(熊本県)