Roles and possible treatment of lipoproteins in diabetic retinopathy

• Project/Area Number: 20890174
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Kumamoto University
• Principal Investigator: HAYASHI Hodeki Kumamoto University, 大学院・先導機構, 特任助教 (90508657)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 神経細胞 / リポプロテイン / 眼疾患 / 糖尿病 / 神経科学 / 脂質

Research Abstract

The aims of this study are to analyze mechanisms of development of diabetic retinopathy and to develop novel treatments for this disorder. Diabetic retinopathy is one of the major complications in diabetes and induces dysfunction of retinal ganglion cells (RGCs). Thus, RGCs in cultures were led injury, analyzed the mechanisms of neuronal death and determined whether lipoproteins protect neurons. This study showed the mechanism of neuroprotection via the receptor of lipoproteins.

Research Products

• [Journal Article] Hayashi H Formation and function of apolipoprotein E-containing lipoproteins in the nervous system (2010)
  • Author(s): Vance JE
  • Journal Title: Biochimica et Biophysica Acta (in press)
  • Peer Reviewed
• [Journal Article] Formation and function of apolipoprotein E-containing lipoproteins in the nervous system (2010)
  • Author(s): Vance JE, Hayashi H
  • Journal Title: Biochimica et Biophysica Acta (印刷中)
  • Peer Reviewed
• [Journal Article] Vance JE Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cγ1 and inhibition of calcineurin (2009)
  • Author(s): Hayashi H, Campenot RB, Vance DE
  • Journal Title: The Journal of Biological Chemistry 284 Pages: 29605-29613
  • Peer Reviewed
• [Journal Article] Protection of neurons from apoptosis by apolipoprotein E-contaning lipoproetins does not require lipoprotein uptake and involes activation of phospholipase Cγ1 and inhibition of calcineurin (2009)
  • Author(s): Hayashi H, Campenot RB, Vance DE, Vance JE
  • Journal Title: The Journal of Biological Chemistry 284 Pages: 29605-29613
  • Peer Reviewed
• [Presentation] リポプロテイン受容体による網膜神経節細胞保護機構の解析 (2009)
  • Author(s): 林秀樹
  • Organizer: 第2回レチナ・リサーチミーティング
  • Place of Presentation: 東京大学医科学研究所
  • Year and Date: 2009-12-12
• [Presentation] リポプロテイン受容体による網膜神経節細胞保護機構の解析 (2009)
  • Author(s): 林秀樹
  • Organizer: 第2回 レチナ・リサーチミーティング
  • Place of Presentation: 東京大学医科学研究所
  • Year and Date: 2009-12-12
• [Presentation] Lipoproteins derived from glia protect retinal ganglion cells from apoptosis (2009)
  • Author(s): 林秀樹
  • Organizer: 第4回緑内障サマーキャンプ
  • Place of Presentation: 大津プリンスホテル
  • Year and Date: 2009-07-31
• [Presentation] Lipoproteins derived from glia protect retinal ganglin cells from apoptosis (2009)
  • Author(s): 林秀樹
  • Organizer: 第4回 緑内障サマーキャンプ
  • Place of Presentation: 大津プリンスホテル
  • Year and Date: 2009-07-31
• [Presentation] グリア細胞由来リポプロテインによる神経細胞保護シグナルの解析 (2009)
  • Author(s): 林秀樹
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-03-17
• [Remarks] ホームページ等
  • URL: http://sendou.kuma-u.jp/research/hayashi.html
• [Remarks]
  • URL: http://sendou.kuma-u.jp/research/hayashi.html
• [Remarks]
  • URL: http://sendou.kuma-u.jp/research/hayashi.html