Novel diagnostic method of Non-alcoholic steatohepatitis used serum free choline score and ^<11>C-choline dynamic PET.

• Project/Area Number: 20890185
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Yokohama City University
• Principal Investigator: FUJITA Koji Yokohama City University, 附属病院, 助教 (30468160)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 非アルコール性脂肪肝炎 / 肝臓リン脂質代謝 / 遊離コリン / 診断 / 内科 / 脂質 / トランスレーショナルリサーチ / 放射線 / 臨床

Research Abstract

1) The development of novel diagnostic method of Non-alcoholic steatohepatitis used serum free choline score.
We discovered to exist the abundant free choline (fCh) in serum in the NASH group than other liver disease and metabolic disorder. We established the method of HPLC system which is more convenient than the present LC-mass system.
2) The development of novel diagnostic method of earlier stage of Non-alcoholic steatohepatitis used ^<11>C-choline dynamic PET system.
We performed the pilot study used ^<11>C-choline dynamic PET system to measure liver phospholipid metabolism in 8 non fatty liver, 14 simple steatosis (SS), and 16 NASH. We certified NASH patients occurred the hypoactivity of liver phospholipid metabolism than other two pathogenesis.
3) Elucidation of the mechanisum of abundant free choline in NASH.
As a progress from SS to NASH, the hepatic expression of apoB100 mRNA and MTTP mRNA were impaired. And then, VLDL synthesis is impaired in NASH, in spite of the presence of abundant fCh in the serum, as a result of some obstacle in choline utilization.

Research Products

• [Journal Article] Dysfunctional VLDL synthesis and release is a key factor in non-alcoholic steato-hepatitis (NASH) pathogenesis. (2009)
  • Author(s): Fujita K, Nozaki Y, Wada K, Yoneda M, Fujimoto Y, Fujitake M, Endo H, Takahashi H, Inamori M, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A
  • Journal Title: Hepatplogy. (in press)
• [Journal Article] Association between angiotensin II type 1 receptor polymorphisms and the occurrence of nonalcoholic fatty liver disease. (2009)
  • Author(s): Yoneda M, Hotta K, Nozaki Y, Endo H, Uchiyama T, Mawatari H, Iida H, Kato S, Fujita K, Takahashi H, Kirikoshi H, Kobayashi N, Inamori M, Abe Y, Kubota K, Saito S, Maeyama S, Wada K, Nakajima A
  • Journal Title: Liver Int.
• [Journal Article] Serum Ferritin Is a Clinical Biomarker in Japanese Patients with Nonalcoholic Steatohepatitis (NASH) Independent of HFE Gene Mutation. (2009)
  • Author(s): Yoneda M, Nozaki Y, Endo H, Mawatari H, Iida H, Fujita K, Yoneda K, Takahashi H, Kirikoshi H, Inamori M, Kobayashi N, Kubota K, Saito S, Maeyama S, Hotta K, Nakajima A
  • Journal Title: Dig Dis Sci.
• [Journal Article] Dysfunctional VLDL synthesis and release is a key factor in non-alcoholic steatohepatitis(NASH)pathogenesis (2009)
  • Author(s): Koji Fujita
  • Journal Title: Hepatology 39 Pages: 963-971
  • Peer Reviewed
• [Journal Article] Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease (2009)
  • Author(s): Yuichi Nozaki, Koji Fujita
  • Journal Title: Journal of Hepatology 51 Pages: 548-556
  • Peer Reviewed
• [Journal Article] Early effects of intravenous administrations of lansoprazole and famotidine on intragastric pH (2009)
  • Author(s): Hiroshi Iida, Koji Fujita
  • Journal Title: Hepato-Gastroenterology 56 Pages: 551-554
  • Peer Reviewed
• [Journal Article] Gender differences in the age-stratified prevalence of erosive esophagitis and Barrett's epithelium in Japan (2009)
  • Author(s): Tomoyuki Akiyama, Koji Fujita
  • Journal Title: Hepato-Gastroenterology 56 Pages: 144-148
  • Peer Reviewed
• [Journal Article] Effective treatment for advanced hepatocellular carcinoma with portal venous invasion using a combination therapy of intra-arterial 5-fluorouracil and subcutaneous pegylated-interferon-alpha-2b (2009)
  • Author(s): Masahiko Inamori, Koji Fujita
  • Journal Title: Dig Dis Sci 54 Pages: 816-818
  • Peer Reviewed
• [Journal Article] Gastrointestinal : Aneurysmal artery in a gastric ulcer following endoscopic hemostasis (2009)
  • Author(s): Yasunobu Abe, Koji Fujita
  • Journal Title: J Gastroenterol Hepatol 24 Pages: 323-323
  • Peer Reviewed
• [Journal Article] Abdominal surgery affects small bowel transit time and completeness of capsule endoscopy (2009)
  • Author(s): Hiroki Endo, Koji Fujita
  • Journal Title: Dig Dis Sci 54 Pages: 1066-1070
  • Peer Reviewed
• [Journal Article] Clinical characteristics of patients with gastric perforation following endoscopic submucosal resection for gastric cancer (2009)
  • Author(s): Yasunobu Abe, Koji Fujita
  • Journal Title: Hepato-Gastroenterology 56 Pages: 921-924
  • Peer Reviewed
• [Journal Article] Does postprandial coffee intake enhance gastric emptying? : a crossover study using continuous real time 13C breath test(BreathID system) (2009)
  • Author(s): Keiko Akimoto, Koji Fujita
  • Journal Title: Hepato-Gastroenterology 56 Pages: 918-920
  • Peer Reviewed
• [Journal Article] Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway (2009)
  • Author(s): Michiko Sugiyama, Koji Fujita
  • Journal Title: Int J Onco 34 Pages: 339-344
  • Peer Reviewed
• [Journal Article] Adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM) (2009)
  • Author(s): Hirokazu Takahashi, Koji Fujita
  • Journal Title: Cancer Science 100 Pages: 29-32
  • NAID: 10024305978
  • Peer Reviewed
• [Journal Article] Incidence of small bowel injury induced by low-dose aspirin : a crossover study using capsule endoscopy in healthy volunteers (2009)
  • Author(s): Hiroki Endo, Koji Fujita
  • Journal Title: Digestion 79 Pages: 44-51
  • Peer Reviewed
• [Journal Article] Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue (2009)
  • Author(s): Hiroyuki Kirikoshi, Koji Fujita
  • Journal Title: Hepatology Research 39 Pages: 553-562
  • Peer Reviewed
• [Journal Article] Association between angiotensin II type 1 receptor(AGTR1)polymorphisms and the occurrence of nonalcoholic fatty liver disease(NAFLD) (2009)
  • Author(s): Masato Yoneda, Koji Fujita
  • Journal Title: Liver International 29 Pages: 1078-1085
  • Peer Reviewed
• [Journal Article] The continuous real-time 13C-octanoate breath test for patients with nonalcoholic steatohepatitis using the BreathID system (2009)
  • Author(s): Hironori Mawatari, Koji Fujita
  • Journal Title: Hepatology Research 79 Pages: 1436-1438
  • Peer Reviewed
• [Journal Article] Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease. (2008)
  • Author(s): Fujita K, Nozaki Y, Wada K, Yoneda M, Endo H, Takahashi H, Iwasaki T, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nagashima Y, Nakajima A
  • Journal Title: Gut. 57 Pages: 1583-91
• [Journal Article] Nitric Oxide Plays a Crucial Role in the Development/Progression of Nonalcoholic Steatohepatitis in the Choline-Deficient, l-Amino Acid-Defined Diet-Fed Rat Model. (2008)
  • Author(s): Fujita K, Nozaki Y, Yoneda M, Wada K, Takahashi H, Kirikoshi H, Inamori M, Saito S, Iwasaki T, Terauchi Y, Maeyama S, Nakajima A
  • Journal Title: Alcohol Clin Exp Res.
• [Journal Article] Gene expression profiling of non-alcoholic steatohepatitis using gene set enrichment analysis. (2008)
  • Author(s): Yoneda M, Endo H, Mawatari H, Nozaki Y, Fujita K, Akiyama T, Higurashi T, Uchiyama T, Yoneda K, Takahashi H, Kirikoshi H, Inamori M, Abe Y, Kubota K, Saito S, Kobayashi N, Yamaguchi N, Maeyama S, Yamamoto S, Tsutsumi S, Aburatani H, Wada K, Hotta K, NakajYoned
  • Journal Title: Hepatol Res. 38(12) Pages: 1204-12
  • NAID: 10023920679
• [Journal Article] Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD). (2008)
  • Author(s): Yoneda M, Hotta K, Nozaki Y, Endo H, Uchiyama T, Mawatari H, Iida H, Kato S, Hosono K, Fujita K, Yoneda K, Takahashi H, Kirikoshi H, Kobayashi N, Inamori M, Abe Y, Kubota K, Saito S, Maeyama S, Wada K, Nakajima A
  • Journal Title: BMC Gastroenterol. 8 Pages: 27-27
• [Journal Article] Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease. (2008)
  • Author(s): Koji Fujita
  • Journal Title: Gut 57 Pages: 1583-1591
  • Peer Reviewed
• [Journal Article] Nitric Oxide Plays a Crucial Role in the Development/Progression of Nonalcoholic Steatohepatitis in the Choline-Deficient, 1-Amino Acid-Defined Diet-Fed Rat Model. (2008)
  • Author(s): Koji Fujita
  • Journal Title: Alcoholism : Clinical and Experimental Research 33 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Effects of body positions on gastric emptying with enteral nutrition : a crossover study using a continuous real time 13C breath test (BreathID system). (2008)
  • Author(s): Tamon Ikeda, Koji Fujita
  • Journal Title: Hepatogastroenterology 55 Pages: 1905-1907
  • Peer Reviewed
• [Journal Article] Gastric surgery is not a risk factor for the development or progression of Barrett's epithelium. (2008)
  • Author(s): Tomoyuki Akiyama, Koji Fujita
  • Journal Title: Hepatogastroenterology 55 Pages: 1899-1904
  • Peer Reviewed
• [Journal Article] Effective treatment for advanced hepatocellular carcinoma with portal venous invasion using a combination therapy of intra-arterial 5-fluorou racil and subcutaneous pegylated-interferon-alpha-2b. (2008)
  • Author(s): Hironori Mawatari, Koji Fujita
  • Journal Title: Hepatogastroenterology 55 Pages: 1776-1777
  • Peer Reviewed
• [Journal Article] Alcohol consumption is associated with an increased risk of erosive esophagitis and Barrett's epithelium in Japanese men. (2008)
  • Author(s): Tomoyuki Akiyama, Koji Fujita
  • Journal Title: BMC Gastroenterology 8 Pages: 58-58
  • NAID: 10021950617
  • Peer Reviewed
• [Journal Article] Differentiating sclerosing cholangitis caused by autoimmune pancreatitis and primary sclerosing cholangitis according to endoscopic duodenal papillary features. (2008)
  • Author(s): Kensuke Kubota, Koji Fujita
  • Journal Title: Gastrointestinal Endoscopy. 68 Pages: 1204-1208
  • Peer Reviewed
• [Journal Article] Association of visceral fat accumulation and plasma adiponectin with rectal dysplastic aberrant crypt foci in a clinical population. (2008)
  • Author(s): Hirokazu Takahashi, Koji Fujita
  • Journal Title: Cancer Science 100 Pages: 29-32
  • NAID: 10025141134
  • Peer Reviewed
• [Journal Article] Inhibition of peroxisome proliferator-activated receptor gamma activity suppresses pancreatic cancer cell motility (2008)
  • Author(s): Atsushi Nakajima, Koji Fujita
  • Journal Title: Cancer Science 99 Pages: 1892-1900
  • Peer Reviewed
• [Journal Article] Plasma Pentraxin3 is a Novel Marker for Nonalcoholic Steatohepatitis (NASH). (2008)
  • Author(s): Masato Yoneda, Koji Fujita
  • Journal Title: BMC Gastroenterology 8 Pages: 53-59
  • Peer Reviewed
• [Journal Article] Adenosquamous carcinoma of the pancreas associated with humoral hy percalcemia of malignancy (HHM). (2008)
  • Author(s): Noritoshi Kobayashi, Koji Fujita
  • Journal Title: Journal of Hepatoblliary Pancreatic Surgery 15 Pages: 531-535
  • NAID: 10024305978
  • Peer Reviewed
• [Journal Article] Abdominal Surgery Affects Small Bowel Transit Time and Completeness of Capsule Endoscopy (2008)
  • Author(s): Hiroki Endo, Koji Fujita
  • Journal Title: Digestive Disease and Sciences 54 Pages: 1066-1070
  • Peer Reviewed
• [Journal Article] Expression of adiponectin receptors, AdipoRl and AdipoR2, in normal colon epithelium and colon cancer tissue (2008)
  • Author(s): Kyoko Yoneda, Koji Fujita
  • Journal Title: Oncology Reports 20 Pages: 479-483
  • Peer Reviewed
• [Journal Article] Severe large-intestine involvement in adult-onset Henoch-Schonlein purpura : successful treatment with factor XIII concentrate (2008)
  • Author(s): Kunihiro Hosono, Koji Fujita
  • Journal Title: Digestion 78 Pages: 9-9
  • Peer Reviewed
• [Journal Article] Tumor fragment impacted at the major duodenal papilla causing obstructive jaundice in a patient with hepatocellular carcinoma (2008)
  • Author(s): Noritoshi Kobayashi, Koji Fujita
  • Journal Title: Gastrointestinal Endoscopy 68 Pages: 999-1000
  • Peer Reviewed
• [Journal Article] Gene expression profiling of non-alcoholic steatohepatitis using gene set enrichment analysis (2008)
  • Author(s): Masato Yoneda, Koji Fujita
  • Journal Title: Hepatology Research 38 Pages: 1204-1212
  • NAID: 10023920679
  • Peer Reviewed
• [Journal Article] Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD) (2008)
  • Author(s): Masato Yoneda, Koji Fujita
  • Journal Title: BMC Gastroenterology Pages: 27-34
  • Peer Reviewed
• [Journal Article] Tumorous arteriovenous malformation in the jejunum missed by capsule endoscopy (2008)
  • Author(s): Hiroki Endo, Koji Fujita
  • Journal Title: Gastrointestinal Endoscopy 68 Pages: 773-774
  • Peer Reviewed
• [Journal Article] Colonic metastasis from hepatocellular carcinoma : manifested by gastrointestinal bleeding. (2008)
  • Author(s): Yuichi Nozaki, Koji Fujita
  • Journal Title: Digestive Disease and Sciences 53 Pages: 3265-3266
  • Peer Reviewed
• [Journal Article] Usefulness of multidetector computed tomography for detection of the obstructive point in a patient with ileus (2008)
  • Author(s): Eiji Sakai, Koji Fujita
  • Journal Title: Digestive Disease and Sciences 53 Pages: 3264-3264
  • Peer Reviewed
• [Journal Article] Characterization of K-ras Gene Mutations in Association with Mucinous Hypersecretion in Intraductal Papillary- Mucinous Neoplasms (2008)
  • Author(s): Noritoshi Kobayashi, Koji Fujita
  • Journal Title: Journal of Hepatobiliary Pancreatic Surgery 15 Pages: 169-177
  • NAID: 10024156439
  • Peer Reviewed
• [Journal Article] Acute appendicitis associated with Peutz-Jeghers-type hamartoma of the appendix (2008)
  • Author(s): Hiroshi Iida, Koji Fujita
  • Journal Title: Digestive Disease and Sciences 53 Pages: 2832-2833
  • Peer Reviewed
• [Journal Article] Neither the presence of metabolic syndrome as defined by the IDF guideline nor an increased waist circumference increased the risk of microvascular or macrovascular complications in Japanese patients with type 2 diabestes (2008)
  • Author(s): Tomoyuki Iwasaki, Koji Fujita
  • Journal Title: Diabetes Research and Clinical Practice 79 Pages: 427-432
  • Peer Reviewed
• [Journal Article] Levovist ultrasonography imaging in intracystic hemorrhage of simple liver cyst (2008)
  • Author(s): Tomoyuki Akiyama, Koji Fujita
  • Journal Title: World Journal of Gastroenterology 14 Pages: 805-807
  • Peer Reviewed
• [Journal Article] Transient erastography in patients with nonalcoholic fatty liver disease(NAFLD). (2007)
  • Author(s): Yoneda M, Yoneda M, Fujita K, Inamori M, Tamano M, Hiriishi H, Nakajima A
  • Journal Title: Gut. 56 Pages: 1330-1
• [Journal Article] High-sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steatohepatitis (NASH) and also of the severity of fibrosis in NASH. (2007)
  • Author(s): Yoneda M, Mawatari H, Fujita K, Iida H, Yonemitsu K, Kato S, Takahashi H, Kirikoshi H, Inamori M, Nozaki Y, Abe Y, Kubota K, Saito S, Iwasaki T, Terauchi Y, Togo S, Maeyama S, Nakajima A
  • Journal Title: J Gastroenterol. 42(7) Pages: 573-82
• [Journal Article] Telmisartan, an angiotensin II type 1 receptor blocker, controls progress of nonalcoholic steatohepatitis in rats. (2006)
  • Author(s): Fujita K, Yoneda M, Wada K, Mawatari H, Takahashi H, Kirikoshi H, Inamori M, Nozaki Y, Maeyama S, Saito S, Iwasaki T, Terauchi Y, Nakajima A
  • Journal Title: Dig Dis Sci. 52(12) Pages: 3455-64
• [Presentation] NASH治療における Telmisartan の適応検討 (2009)
  • Author(s): 藤田浩司
  • Organizer: 第38回日本肝臓学会西部会
  • Place of Presentation: 米子
  • Year and Date: 2009-12-04
• [Presentation] Measurement of serum free choline score may be used in general practice as initial screening tools of NAFLD before liver biopsy (2009)
  • Author(s): 藤田浩司
  • Organizer: 17^<th> UEGW
  • Place of Presentation: Boston, UK
  • Year and Date: 2009-11-05
• [Presentation] NASH治療における Telmisartan の適応検討 (2009)
  • Author(s): 藤田浩司
  • Organizer: 第17回日本消化器関連学会週間(JDDW)
  • Place of Presentation: 京都
  • Year and Date: 2009-10-15
• [Presentation] Dysfunctional VLDL synthesis is a key factor in non-alcoholic steatohepatitis(NASH)pathogenesis (2009)
  • Author(s): 藤田浩司
  • Organizer: 第44回ヨーロッパ肝臓学会年会(EASL)
  • Place of Presentation: Italy
  • Year and Date: 2009-07-11
• [Presentation] NAFLD病態における肝ミクロソームTG輸送蛋白(MTTP)が果たす意義 (2009)
  • Author(s): 藤田浩司, 野崎雄一, 馬渡弘典, 米田正人, 桐越博之, 斉藤聡, 中島淳
  • Organizer: 第45回日本肝臓学会総会ワークショップ
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-04
• [Presentation] NASH/NAFLD診断のためのLipoSEARCH^(R)システムを用いた簡易コリン測定法の開発 (2009)
  • Author(s): 中島淳, 斎藤聡, 桐越博之, 野崎雄一, 藤田浩司, 米田正人, 佐々木裕樹
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-04
• [Presentation] NAFLD病態における肝ミクロソームTG輸送蛋白(MTTP)が果たす意義 (2009)
  • Author(s): 藤田浩司
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-04
• [Presentation] Dysfunctional VLDL synthesis and release is a key factor in non-alcoholic steatohepatitis (NASH) progression (2009)
  • Author(s): Koji Fujita, Yuichi Nozaki, Masato Yoneda, Hiroyuki Kirikoshi, Satoru Saito, Atsushi Nakajima
  • Organizer: Digestive Disease Week 2009
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-06-02
• [Presentation] Dysfunctional VLDL synthesis and release is a key factor in non-alcoholic steatohepatitis(NASH)progression (2009)
  • Author(s): 藤田浩司
  • Organizer: DDW2009
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-06-01
• [Presentation] 肝ミクロソームTG輸送蛋白(MTTP)がNAFLD病態進展に与える影響 (2009)
  • Author(s): 藤田浩司, 野崎雄一, 米田正人, 留野渉, 加藤真吾, 内山崇, 渡辺誠太郎, 馬渡弘典, 飯田洋, 細野邦広, 遠藤宏樹, 高橋宏和, 阿部泰伸, 稲森正彦, 桐越博之, 小林規俊, 島村健, 窪田賢輔, 斉藤聡, 中島淳
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-07
• [Presentation] Novel diagnostic approach for NASH using [11C] choline dynamic PET imaging. (2008)
  • Author(s): Koji Fujita, Yuichi Nozaki, Masato Yoneda, Hiroki Endo, Hirokazu Takahashi, Masahiko Inamori, Yasunobu Abe, Noritoshi Kobayashi, Hiroyuki Kirikoshi, Kensuke Kubota, Satoru Saito, Atsushi Nakajima
  • Organizer: 16th UEGW Oral presentation
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2008-10-21
• [Presentation] 非肥満NASH患者に対するVit. E+EPL併用療法の有用性. (2008)
  • Author(s): 藤田浩司
  • Organizer: 第16回日本消化器関連学会週間
  • Place of Presentation: 品川
  • Year and Date: 2008-10-02
• [Presentation] 高血圧のみ合併したNASH患者に対するARBの有用性 (2008)
  • Author(s): 藤田浩司
  • Organizer: 第16回日本消化器関連学会週間
  • Place of Presentation: 品川
  • Year and Date: 2008-10-02
• [Presentation] 脂質に注目したNASHの病態解析 (2008)
  • Author(s): 藤田浩司
  • Organizer: 横浜肝疾患研究会
  • Place of Presentation: 横浜
  • Year and Date: 2008-07-11
• [Presentation] Novel diagnostic approach for NASH using [11C] choline dynamic PET imaging. (2008)
  • Author(s): Koji Fujita, Yuichi Nozaki, Masato Yoneda, Hiroki Endo, Hirokazu Takahashi, Masahiko Inamori, Yasunobu Abe, Noritoshi Kobayashi, Hiroyuki Kirikoshi, Kensuke Kubota, Satoru Saito, Atsushi Nakajima
  • Organizer: Digestive Disease Week 2008
  • Place of Presentation: San Diego, USA
  • Year and Date: 2008-05-20
• [Presentation] Novel diagnostic approach for NASH using [11C] choline dynamic PET imaging. Yokohama City University Division of Gastroenterology (2008)
  • Author(s): Koji Fujita
  • Organizer: Digestive Disease Week 2008
  • Place of Presentation: San Diego, USA
  • Year and Date: 2008-05-20
• [Presentation] Novel diagnostic approach for NASH using [11C]choline dynamic PET imaging. (2008)
  • Author(s): Koji Fujita
  • Organizer: 16^<th> UEGW
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2008-05-20
• [Presentation] 坑血小板薬のNAFLD病態改善効果- NAFLD病態モデルラットを用いた検討- (2008)
  • Author(s): 藤田浩司, 野崎雄一, 米田正人, 馬渡弘典, 飯田洋, 遠藤宏樹, 秋山智之, 米田恭子, 高橋宏和, 後藤歩, 廣川智, 阿部泰伸, 稲森正彦, 桐越博之, 小林規俊, 窪田賢輔, 斉藤聡, 中島淳
  • Organizer: 日本消化器病学会総会
  • Year and Date: 2008-05-10
• [Presentation] 坑血小板薬のNAFLD病態改善効果-NAFLD病態モデルラットを用いた検討- (2008)
  • Author(s): 藤田浩司
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-10
• [Presentation] 血清コリン測定および11C-コリンPET-CTを用いたNASH, NAFLDの新しい診断法～肝脂質排出能に着目したNAFLD診断～. (2007)
  • Author(s): 藤田浩司, 米田正人, 中島淳
  • Organizer: 日本消化器病学会総会
• [Presentation] Novel Therapeutic Approach for Nonalcoholic Fatty Liver Disease( NAFLD) using Antiplatelet Agents in an Animal Model. (2007)
  • Author(s): Koji Fujita, Yuichi Nozaki, Masato Yoneda, Masahiko Inamori, Hiroyuki Kirikoshi, Satoru Saito, Atsushi Nakajima
  • Organizer: AASLD
• [Presentation] 血清コリン測定および11C-コリンPET-CTを用いたNASH, NAFLDの新しい診断法～肝脂質排出能に着目したNAFLD診断～. (2007)
  • Author(s): 藤田浩司, 野崎雄一, 米田正人, 中島淳
  • Organizer: 第4回酸化ストレスと肝研究会
  • Place of Presentation: 博多
• [Presentation] Nonalcoholic Steatohepatitis~The role of Extrahepatic Nitric oxide ~ (2006)
  • Author(s): Koji Fujita, Masato Yoneda, Masahiko Inamori, Hiroyuki Kirikoshi, Tomoyuki Iwasaki, Yasuo Terauchi, Atsushi Nakajima
  • Organizer: アメリカDDW
• [Presentation] 非アルコール性脂肪性肝炎病態におけるNitric Oxideの役割～高脂肪高カロリー食投与肥満モデルマウスにおける検討～. (2006)
  • Author(s): 藤田浩司, 米田正人, 野崎雄一, 馬渡弘典, 秋本恵子, 飯田洋, 冨本彩子, 遠藤宏樹, 米満恭子, 秋山智之, 藤澤聡郎, 高橋宏和, 阿部泰伸, 稲森正彦, 桐越博之, 窪田賢輔, 斉藤聡, 中島淳
  • Organizer: 日本消化器病学会総会
• [Book] NAFLD/NASHの診断. 「最新医学」第63巻9号 (2008)
  • Author(s): 野崎雄一, 藤田浩司, 米田正人, 前山史郎, 中島淳
• [Book] Which is the best monitoring study (tumor marker, computed tomography or 18F-fluoro-2-deoxy-D-glucose positron emission tomography) to evaluate efficacy of chemotherapy on unresectable pancreatic cancer? (2008)
  • Author(s): 藤田浩司
  • Total Pages: 6
  • Publisher: 癌と化学療法
• [Book] NASH病態形成におけるiNOS由来一酸化窒素の意義 (2008)
  • Author(s): 藤田浩司
  • Total Pages: 2
  • Publisher: G. I. Research
• [Book] NAFLD/NASHの診断 (2008)
  • Author(s): 藤田浩司
  • Total Pages: 5
  • Publisher: 最新医学
• [Book] レーザー治療(適応と成績, 合併症) (2008)
  • Author(s): 藤田浩司
  • Total Pages: 5
  • Publisher: 消化器外科
• [Book] 食物アレルギー (2008)
  • Author(s): 藤田浩司
  • Total Pages: 4
  • Publisher: Pharmavision
• [Book] 血清Choline測定によるNASHの新しい診断法.アルコールと医学生物学27巻 (2007)
  • Author(s): 藤田浩司, 野崎雄一, 米田正人, 稲森正彦, 桐越博之, 斉藤聡, 中島淳
• [Book] 非アルコール性脂肪性肝炎(NASH)の病態進展におけるiNOS由来Nitric Oxideの役割. アルコールと医学生物学26巻 (2006)
  • Author(s): 藤田浩司, 米田正人, 野崎雄一, 稲森正彦, 桐越博之, 齋藤聡, 岩崎知之, 寺内康夫, 前山史朗, 和田孝一郎, 中島淳
• [Book] 肝外性NOのNASH病態進展有力因子の検討. G. I. Research (0918-9408)14巻4号 (2006)
  • Author(s): 藤田浩司, 米田正人, 秋山智之, 池田多聞, 池田郁子, 藤澤聡郎, 藤澤信隆, 高橋宏和, 稲森正彦, 阿部泰伸, 桐越博之, 窪田賢輔, 斉藤聡, 中島淳
• [Book] 肝脂質排出能に着目したNASH診断の検討～11C-Choline dynamic PETを用いて
  • Author(s): 藤田浩司, 野崎雄一, 米田正人, 中島淳
• [Patent(Industrial Property Rights)] 非アルコール性脂肪肝疾患の診断方法 (2008)
  • Inventor(s): 藤田浩司
  • Industrial Property Rights Holder: 藤田浩司
  • Acquisition Date: 2008-07-18
• [Patent(Industrial Property Rights)] 非アルコール性脂肪肝障害の検査方法 (2008)
  • Inventor(s): 藤田浩司
  • Industrial Property Rights Holder: 藤田浩司
  • Acquisition Date: 2008-07-22
• [Patent(Industrial Property Rights)] 非アルコール性脂肪肝障害の検査方法 (2008)
  • Inventor(s): 藤田浩司
  • Industrial Property Rights Holder: 藤田浩司
  • Industrial Property Number: 2008-188560
  • Filing Date: 2008-07-22
• [Patent(Industrial Property Rights)] 脂肪肝炎の診断及び/又は治療における血清コリン値の有用性
  • Inventor(s): 藤田浩司
  • Industrial Property Rights Holder: 藤田浩司
• [Patent(Industrial Property Rights)] 血液中一酸化窒素代謝物量測定による内臓脂肪量非侵襲的測定法
  • Inventor(s): 藤田浩司
  • Industrial Property Rights Holder: 藤田浩司
• [Patent(Industrial Property Rights)] 11C-Choline PETを用いた非アルコール性脂肪性肝障害の診断・評価法の発明
  • Inventor(s): 藤田浩司
  • Industrial Property Rights Holder: 藤田浩司
• [Patent(Industrial Property Rights)] 血中カイロミクロン及びVLDL測定による非アルコール性脂肪肝・脂肪肝炎の重症度判定・モニター法の発明
  • Inventor(s): 藤田浩司
  • Industrial Property Rights Holder: 藤田浩司
• [Patent(Industrial Property Rights)] 脂肪性肝疾患の診断方法、診断装置、診断プログラム、診断薬及び脂肪性肝疾患用治療薬のスクリーニング方法
  • Inventor(s): 藤田浩司
  • Industrial Property Rights Holder: 藤田浩司