| Project/Area Number |
20890191
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
HORINAKA Mano Kyoto Prefectural University of Medicine, 医学研究科, 助教 (80512037)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 癌 / microRNA / TRAIL / DR5 / アポトーシス / 予防 / p53 / 食品成分 / アボトーシス / がん / p^<53> |
|---|
| Research Abstract |
miR-221/222 contributes to TRAIL resistance. I built plasmid to evaluate a promoter activation level of miR-221/222 for the screening of the food composition with the repressor activity of miR-221/222.
I found that PUMA was a new target gene of miR-221/222. TRAIL resistance mechanism and association with miR-221/222 might be proved.
As a TRAIL-sensitizing compounds, we found six kinds of materials newly. Furthermore, as the ingredient which enhanced TRAIL expression level, we reported lactic acid bacterium.
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